董凯


的个人主页 http://teacher.nwpu.edu.cn/2016010236

  被浏览次数:492

基本信息 The basic information

董凯

生命学院

博士研究生毕业

医学博士

讲师(高校)

药学-药剂学

dongkai120@nwpu.edu.cn

15209281970

工作经历 Work Experience

2016.12-至今 西北工业大学 生命学院 讲师

教育经历 Education Experience

2013-2016  西安交通大学     药物分析学  博士

2011-2013  西安交通大学     药剂学         硕士

2006-2010  陕西中医药大学 中药学         学士

教育教学 Education And Teaching

主讲课程:

本科生辅修课程《植物学》

本科生专业课《基因工程》


科学研究 Scientific Research

研究方向:

药物传递系统;细胞内源性因子检测;超分子系统构建与应用

科研项目:

1.国家自然科学基金青年基金项目:双探针共载肿瘤渗透性纳米荧光检测系统的构建及其在乳腺癌PDT精准治疗中的应用,81803491,2019/01-2021/12;

2.中国博士后科学基金面上项目:肿瘤渗透性纳米检测系统对乳腺癌PDT治疗的指导研究,2018M633584;

3.中央高校基本科研业务费-西北工业大学新进教师科研启动费,3102017OQD043氧化还原响应性纳米胶束的构建及其在多药耐药肿瘤中的应用研究2017/01-2018/12




学术成果 Academic Achievements

发表论文:

[1]      Dong K, Yang C, Yan Y, et al. Investigation of the intracellular oxidative stress amplification, safety and anti-tumor effect of a kind of novel redox-responsive micelle. Journal of Materials Chemistry B. 2018, 6 (7): 1105-1117.

[2]      Dong K, Zhang HF, Yan Y, Sun JY, Dong YL, Wang K, Zhang L, Shi XP, Xing JF. Improvement of side-effects and treatment on the experimental colitis in mice of a resin microcapsule loading hydrocortisone sodium succinate. Drug Development and Industrial Pharmacy. 2017, 43(3): 448-457.

[3]      Dong K, Yan Y, Wang PC, Shi XP, Zhang L, Wang K, Xing JF, Dong YL. Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance. International Journal of Nanomedicine. 2016, 11: 5109-5123.

[4]      Dong K, Zeng AG, Wang ML, Dong YL, Wang K, Guo CN, Yan Y, Zhang L, Shi XP, Xing JF. In vitro and in vivo study of a colon-targeted resin microcapsule loading a novel prodrug, 3, 4, 5-tributyryl shikimic acid. RSC Advances. 2016, 6: 16882-16890.

[5]      Dong K, Dong YL, You CY, Xu W, Huang XY, Yan Y, Zhang L, Wang K, Xing JF. Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel. Drug Delivery. 2016, 23(1): 174-184.

[6]      Dong K, Dong YL, You CY, Xu W, Huang XY, Yan Y, Zhang L, Wang K, Xing JF. Assessment of the safety, targeting, and distribution characteristics of a novel pH-sensitive hydrogel. Colloid and Surface B-Biointerfaces. 2014, 123: 965-973.

[7]      Dong K, Xu W, You CY, Xing JF, Zhang JY, Gao Y, Wang K. Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization. International Journal of Polymeric Materials and Polymeric Biomaterials. 2013, 62(14): 726-732.

[8]      Zeng AG#, Dong K#, Wang ML, Sun JY, Dong YL, Wang K, Guo CN, Yan Y, Zhang L, Shi XP, Xing JF. Investigation of the colon-targeting, improvement on the side-effects and therapy on the experimental colitis in mouse of a resin microcapsule loading dexamethasone sodium phosphate. Drug Delivery. 2016, 23(6): 1992-2002.

[9]      Wang K#, Dong K#, Yan Y, Xu W, Zhang L, Zhao GL, Xing JF. In vitro and in vivo study of a colon-targeting pH-sensitive hydrocortisone sodium succinate hydrogel. RSC Advances. 2015, 5(98): 80625-80633.

[10]  Sun JY, You CY, Dong K, You HS, Xing JF. Anti-inflammatory, analgesic and antioxidant activities of 3, 4-oxo-isopropylidene-shikimic acid. Pharmaceutical biology. 2016, 54(10): 2282-2287.

[11]  You CY, Dong YL, Dong K, Xu W, Yan Y, Zhang L, Wang K, Xing JF. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydrate Polymers. 2015, 130: 243-253.

[12]  Xu W, Xing JF, Dong K, You CY, Yan Y, Zhang L, Zhao GL, Chen YL, Wang K. Application of traditional Chinese medicine preparation in targeting drug delivery system. Drug Delivery. 2014, 22(3):1-8.

[13]  Xing JF, You CY, Dong K, Sun JY, You HS, Dong YL, Sun JN. Ameliorative effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats. International Immunopharmacology. 2013, 15(3): 524-531.

[14]  Wang K, Li WF, Xing JF, Dong K, Gao Y. Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel. European Journal of Pharmaceutics and Biopharmaceutics. 2012, 82(2): 332-339.

[15]  Yan Y, Zhang HF, Sun JY, Wang PC, Dong K, Dong YL, Xing JF. Enhanced transdermal delivery of sinomenine hydrochloride by ethosomes for anti-inflammatory treatment. Journal of Drug Delivery Science and Technology. 2016, 36: 201-207.

[16]  Wang K, Yan Y, Zhao GL, Xu W, Dong K, You CY, Zhang L, Xing JF. In vitro and in vivo application of Hydroxypropyl-β-cyclodextrin-grafted polyethyleneimine used as a transdermal penetration enhancer. Polymer Chemistry. 2014, 5(16): 4658-4669.

[17]  Yan Y, Xing JF, Xu W, Zhao GL, Dong K, Zhang L, Wang K. Hydroxypropyl-β-cyclodextrin grafted polyethyleneimine used as transdermal penetration enhancer of diclofenac sodium. International Journal of Pharmaceutics. 2014, 474(1-2): 182-192.

[18]  Xing JF, Sun JN, Sun JY, You CY, Dong K, Lv J, Dong YL. Protective Effects of 3, 4-Oxo-isopropylidene-Shikimic Acid on Experimental Colitis Induced by Trinitrobenzenesulfonic Acid in Rats. Digest Diseases and Sciences. 2012, 57: 2045-2054.

[19]  Wang K, Fu Q, Chen X, Gao Y, Dong K. Preparation and characterization of pH-sensitive hydrogel for drug delivery system. RSC Advances. 2012, 2: 7772-7780.

[20]  Shi JY, Huang H, Li JX, Lei P, Zhang, YN, Dong K, Yiu SM. TMFUF: a triple matrix factorization-based unified framework for predicting comprehensive drug-drug interactions of new drugs. BMC bioinformatics. 2018, 19 (Suppl 14): 411.

[21]  闫占社,黄飚,麻纪斌,翟帆,董凯。茴拉西坦分散片溶出度测定方法研究。西北药学杂志。2013,28(2):186-188。

[22]  麻纪斌,曲秦,董凯,翟帆,李宗霖,陈雁,邢建峰。布洛芬原位凝胶体外溶蚀和药物释放度考察。西北药学杂志。2013,28(5):513-514。

专利:

[1]     王珂,邢建峰,游翠玉,许维, 董凯 一种结肠靶向型 pH敏感水凝胶及其制备方法和应用,2016.02.24 中国, 201310303819.0

[2]     肖志强,邢建峰,董亚琳,郭辰宁,马丽,游翠玉, 董凯,谢姣, 一种化合物及其制备方法和抗溃疡性结肠炎用途, 2015.06.17 中国, 201310232307.X

[3]     董亚琳,邢建峰,郭辰宁,马丽,孙金钥, 董凯,游翠玉,谢姣, 一种化合物及其制备方法和抗溃疡性结肠炎用途, 2015.04.29 中国, 201310232459.X

[4]     麻纪斌,邢建峰,董亚琳,马丽,郭辰宁, 董凯,游翠玉,谢姣, 3,3’-偶氮双[6-(丁酰氧基)苯甲酸]及其制备方法和应用, 2015.01.07 中国, 201310232458.5

[5]     王珂,邢建峰, 董凯,许维, 一种高分子透皮吸收促进剂及其制备方法和应用,2014.11.05 中国, 201310012315.3

社会兼职 Social Appointments

中国生物材料学会会员,中国药学会会员