胡丽芳

的个人主页 http://teacher.nwpu.edu.cn/hulifang

基本信息 The basic information

胡丽芳

生命学院

博士研究生毕业

工学博士

讲师(高校)

hulifang@nwpu.edu.cn

工作经历 Work Experience

2013/12~2015/12,西北工业大学生命学院,博士后

2016/01~今,西北工业大学生命学院,助理教授,硕士研究生导师

教育经历 Education Experience

2009/4~2013/12:西北工业大学,人机与环境工程,工学博士

2006/9~2009/3:西北工业大学,生物医学工程,工学硕士

2002/9~2006/6:陕西师范大学,生物学(基地班),理学学士 

教育教学 Education And Teaching

1. 讲授课程:

    本科生课程:

           《分子生物学》,《生命科学导论》

    研究生课程:

           《细胞工程》,《细胞培养技术》

2. 指导2017届本科毕业生获得西北工业大学本科优秀毕业论文

3. 指导本科生大学生创新训练项目2项:

    (1) MACF1基因敲除小鼠基因型与表型鉴定研究,(No. 201510699284), 2017.6-2018.6

     (2) MACF1基因敲除小鼠基因型与表型鉴定研究,(No. 201510699284), 2015.6-2016.6


荣誉获奖 Awards Information


2018年:西北工业大学优秀青年教师奖

2016年:陕西省细胞生物学学会授予“优秀青年论文鼓励奖” .  

2014年:陕西省细胞生物学学会授予“优秀青年论文三等奖” .

2014年:国际空间研究委员会(COSPAR)授予“青年科学家杰出论文奖(Outstanding Paper Award for Young Scientists)”

科学研究 Scientific Research

研究方向:骨质疏松发生机制研究;空间生物学,骨生物学,细胞分子生物学

主持科研项目(13项):

1.国家自然科学基金面上项目:“MACF1结合CDK12参与模拟失重抑制骨形成的作用及机制(No. 81772017), 2018.1-2021.12

2.国家自然科学基金青年项目:MACF1通过Wnt/β-catenin信号通路参与模拟失重抑制成骨细胞分化的机制研究(No. 31400725), 2015.1-2017.12

3. 陕西省自然科学基金面上项目MACF1调节细胞骨架重排在成骨细胞感知与响应失重环境的作用(No. 2018JM3040), 2018.1-2019.12

4.陕西省高校科协青年人才托举计划项目MACF1结合CDK12参与老年性骨质疏松症发生的作用及机制(20170401), 2018.1-2019.12

5.中国博士后科学基金特别资助项目:“MACF1调节细胞骨架在MSC分化与老年骨质疏松症中的作用, 2018.3-2019.12

6.中国博士后基金面上项目(一等)“MACF1调节细胞骨架重排参与失重抑制骨形成的作用研究”(No.2017M610653)2017.3-2018.12

7.陕西省博士后基金(一等)“MACF1调节细胞骨架重排参与老年性骨质疏松症发生的作用研究” 2017.1-2018.12

8.中国博士后科学基金特别资助项目:“miR-138-5p在模拟失重抑制骨形成中的作用及机制(No. 2015T81051), 2015.9-2017.9

9.中国博士后科学基金面上项目(二等)“MACF1分子参与模拟失重条件抑制骨形成的作用研究(No. 2014M562450), 2014.7-2015.12

10.陕西省自然科学基金青年人才项目:MACF1参与模拟失重条件影响前成骨细胞迁移的作用及机制研究”(No. 2015JQ3076), 2015.1-2016.12

11.中央高校基本科研业务费资助项目:一种新的非编码RNA调控MACF1参与骨形成的分子机制研究”(No. 3102016ZY037)2016.1-2017.12

12.中央高校基本科研业务费资助项目:前成骨细胞向骨形成表面迁移的分子机制研究(No. 3102014JKY15007), 2014.5-2016.5

13.西北工业大学新进教师科研启动费:非编码RNA通过调节MACF1参与成骨细胞分化与骨形成的机制研究 (No. 3102016QD015)2016.1-2017.12


 


 

     

    学术成果 Academic Achievements

    代表性文章:

    (1) Lifang Hu, Chong Yin, Fan Zhao, Arshad Ali, Jianhua Ma, Airong Qian*. Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment. International Journal of Molecular Science. 2018, 19(2): 360.

    (2) Lifang Hu, Peihong Su, Chong Yin, Runzhi Li, Kun Yan, Zhihao Chen, Dijie Li, Ge Zhang, Liping Wang, Zhiping Miao*, Airong Qian*, Cory J. Xian. Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis. Journal of Cellular Physiology. 2018, 233(2): 1574-1584.

    (3) Lifang Hu, Yunyun Xiao, Zhipeng Xiong, Fan Zhao, Chong Yin, Yan Zhang, Peihong Su, Dijie Li, Zhihao Chen, Xiaoli Ma, Ge Zhang, Airong Qian*. MACF1, versatility in tissue-specific function and in human disease. Seminars in Cell & Developmental Biology. 2017, 69: 3-8.

    (4) Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Yan Zhang, Peng Shang, Tuanmin Yang, Airong Qian*. Isoforms, structures, and functions of versatile spectraplakin MACF1. BMB Reports. 2016, 49(1): 37-44.

    (5) Lifang Hu, Peihong Su, Runzhi Li, Kun Yan, Zhihao Chen, Peng Shang, Airong Qian*. Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells. BMB Reports. 2015, 48(10): 583-588.

    (6) Lifang Hu, Jingbao Li, Airong Qian, Fei Wang, Peng Shang*. Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition. Cell Biology International. 2015, 39(4): 364-372.

    (7) Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge Zhang, Peng Shang, Airong Qian*. Response and adaptation of bone cells to simulated microgravity. Acta Astronautica, 2014, 104(1): 396-408. 

    (8) Lifang Hu, Airong Qian, Yang Wang, Shengmeng Di, Peng Shang*. Inhibitory effect of simulated microgravity on differentiating preosteoblasts. Advances in Space Research, 2013, 51(1), 107-114. 

    (9)  Airong Qian, Lifang Hu. Spectraplakins, versatile roles in physiology and pathology. Seminars in Cell & Developmental Biology. 2017, 69: 1-2.

    (10) Arshad Ali, Lifang Hu, Fan Zhao, Wuxia Qiu , Pai Wang, Xiaoli Ma, Yan Zhang, Lei Chen, Airong Qian*. BPAG1, a distinctive role in skin and neurological diseases. Seminars in Cell & Developmental Biology. 2017, 69: 34-39.

    (11) Airong Qian, Lifang Hu, Xiang Gao, Wei Zhang, Shengmeng Di, Zongcheng Tian, Dachuan Yin, Yuanyuan Weng, Peng Shang. Large gradient high magnetic field affects the association of MACF1 with actin and microtubule cytoskeleton. Bioelectromagnetics. 2009, 30(7): 545-555.

    (12) Yan Zhang#, Chong Yin#, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang*, Airong Qian*, Cory J. Xian. MACF1 overexpression by transfecting the 21-kbp large plasmid PEGFP-C1A-ACF7 promotes osteoblast differentiation and bone formation. Human Gene Therapy. 2018, 29(2):259-270.

    (13) Chong Yin#, Yan Zhang#, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang*, Airong Qian*, Cory J. Xian. Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation. Journal of Cellular Physiology. 2018, 233(7):5405-5419.

    (14)  胡丽芳,骞爱荣,李迪杰,李京宝,商澎*. 不同分化阶段的成骨细胞对强磁重力环境的响应中国细胞生物学学报. 2013, 35(7): 950-957. 

    (15) 胡丽芳,骞爱荣,商澎*. 骨硬化蛋白与骨代谢. 生命的化学. 2011, 31(5): 613-618.

    (16) 胡丽芳,骞爱荣,商澎*. Vinculin在细胞响应力学刺激中的作用. 中国生物化学与分子生物学报. 2009, 25(9): 805-810.

    (17) 胡丽芳,骞爱荣,杨鹏飞,张维,谢丽,商澎*. 中等强度静磁场对白血病细胞增殖和细胞周期的影响. 第四军医大学学报. 2009, 30(5): 397-400. 

    国家发明专利:

     (1) 骞爱荣,胡丽芳,印崇,赵帆,陈志浩,张琰,马剑华,苏佩红,李迪杰,仇伍霞,马小莉,王牌。MACF1基因及其表达产物在制备诊断和治疗骨质疏松症药物中的应用。公开号:CN106148520A

    (2) 骞爱荣,胡丽芳,印崇,张琰,马剑华,赵帆,陈志浩,李迪杰,李思宇,马小莉,仇伍霞,杨超飞,王牌,苏佩红。miR-489-3p在制备诊断和治疗人骨质疏松症药物中的应用。公开号:CN106011264A

    (3) 骞爱荣,胡丽芳,马剑华,李思宇,赵帆,陈志浩,李迪杰,陈楚,杨团民,印崇,苏佩红,马小莉,张琰,仇伍霞,张茹,王牌,杨超飞。老年骨质疏松性骨折的血清microRNA诊断标志物及其诊断试剂盒。公开号:CN106591487A

    (4) 骞爱荣,胡丽芳,王牌,马小莉,赵帆,仇伍霞,张茹,陈蕾,印崇,李迪杰,苏佩红,陈志浩,张琰,杨超飞,李思宇。MACF1定点转基因小鼠模型构建方法,发明专利,公开号:CN107446950A

    (5) 骞爱荣,胡丽芳,仇伍霞,马小莉,赵帆,张茹,王牌,陈蕾,印崇,陈志浩,苏佩红,李迪杰,张琰,李思宇,杨超飞。MACF1基因在成骨细胞中条件性敲除的小鼠模型的构建及应用。发明专利,公开号:CN107114311A

    (6) 骞爱荣,马小莉,胡丽芳,赵帆,张茹,仇伍霞,王牌,苏佩红,陈志浩,李迪杰,印崇,苗治平,陈蕾。间充质干细胞中MACF1基因条件性敲除小鼠模型的建立及其应用,发明专利,公开号:CN107047452A

    (7) 骞爱荣,商澎,胡丽芳,李润芝,苏佩红,印崇,闫琨,陈志浩,戚依朵,孙瑜隆. 抑制小鼠MACF1基因表达的shRNA序列及其应用。专利号:ZL 201410631379.6

    (8) 骞爱荣,印崇,苗治平,张琰,胡丽芳,陈志浩,赵帆,李迪杰,马剑华,苏佩红,马小莉,仇伍霞,杨超飞,李思宇,王牌。长链非编码RNA Lnc-DIF的应用。公开号:CN106676177A

    (9) 骞爱荣,陈志浩,Yasir Arfat,印崇,胡丽芳,赵帆,李迪杰,张琰,李润芝,苏佩红,马小莉,仇伍霞。力学敏感的miR-138-5p 作为药物靶点在骨骼肌肉系统疾病中应用。公开号:CN105169411A

    (10) 骞爱荣,马剑华,赵帆,陈志浩,胡丽芳,李迪杰,印崇,马小莉,苏佩红。与老年性骨质疏松相关微小RNA的寡核苷酸化合物的应用。公开号:CN106167824A

    代表性学术交流:

    (1) Lifang Hu, Chong Yin, Zixiang Wu, Zizhan Huang, Airong Qian*. MACF1 Promotes Osteoblast Differentiation by Sequestering Repressors of Wnt Signaling. ASBMR 2018 Annual Meeting, Montreal, Canada, Sep. 27-Oct. 1, 2018. (Poster).

    (2) Lifang Hu, Chong Yin, Zixiang Wu, Zizhan Huang, Peihong Su, Yan Zhang, Zhihao Chen, Airong Qian*. Mechanical sensitive molecule MACF1 promotes osteoblast differentiation. 中国空间科学学会空间生命专业委员会第二十二届学术研讨会暨中国宇航学会航天医学工程与空间生物学专业委员会第六届学术研讨会, 苏州, 中国, 20181011-13. (口头报告)

    (3) Lifang Hu, Zhihao Chen, Airong Qian*. MicroRNA-138-5p targets MACF1 to inhibit bone formation under simulated microgravity condition. Sino-German Symposium on Space Biomaterials and Systems Chemistry, Xi’an, China, Oct. 12-16, 2017. (Oral presentation).

    (4) Lifang Hu, Peihong Su, Chong Yin, Yan Zhang, Zhihao Chen, Dijie Li, Ge Zhang, Liping Wang, Dongmei Jiang, Airong Qian*, Cory J. Xian. Knockdown of microtubule actin crosslinking factor 1 induces rearrangement of F-actin and inhibits osteoblast differentiation. The 3rd International Musculoskeletal Research Conference. Xinjiang, China, Aug. 16-19, 2017. (Poster).

    (5) Lifang Hu, Peihong Su, Chong Yin, Yan Zhang, Runzhi Li, Kun Yan, Zhihao Chen, Dijie Li, Ge Zhang, Zhiping Miao*, Airong Qian*. Microtubule actin crosslinking factor 1 promotes osteoblast differentiation and is important for β-catenin signaling. International Conference on Environment and Human Health Systems Engineering, Jul. 8-9, 2017. (Oral presentation).

    (6) Lifang Hu, Peihong Su, Chong Yin, Runzhi Li, Kun Yan, Ge Zhang, Peng Shang, Airong Qian*. MACF1 positively regulates osteoblast differentiation via β-catenin signaling. 2016 ICORS Meeting, Xi’an, China, Sept. 21-25, 2016. (Oral presentation).

    (7) Lifang Hu, Peihong Su, Chong Yin, Yan Zhang, Chaofei Yang, Yunyuan Xiao, Runzhi Li, Kun Yan, Ge Zhang, Peng Shang, Airong Qian*. MACF1 positively regulates osteoblast differentiation via β-catenin signaling. 中国宇航学会航天医学工程与空间生物学专业委员会第五届学术研讨会暨中国空间科学学会空间生命专业委员会第二十一届学术研讨会, 深圳, 中国, 20161216-18 (墙报).

    (8) Lifang Hu, Peihong Su, Chong Yin, Runzhi Li, Kun Yan, Ge Zhang, Peng Shang, Airong Qian*. MACF1 positively regulates osteoblast differentiation via β-catenin signaling. 陕西省细胞生物学学会2016年学术年会, 西安, 中国, 20161111-13.

    (9) Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Kun Yan, Ge Zhang, Peng Shang, Airong Qian*. A novel role of MACF1: positively regulates osteoblast differentiation. ASBMR 2015 Annual Meeting, Seattle, USA, Oct. 9-12, 2015. (Poster)

    (10) Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Kun Yan, Ge Zhang, Peng Shang, Airong Qian*. The role of MACF1 in regulating osteoblast differentiation. The International Chinese Musculoskeletal Research Society (ICMRS) Conference and Xiangya Osteoporosis Forum, Changsha, China. 2015, April 9-11. (Poster)

    (11) Lifang Hu, Airong Qian, Yang Wang, Shengmeng Di, Peng Shang*. The inhibitory effect on differentiation of osteoblasts cultured on random positioning machine, 5th China-Germany Workshop on Microgravity and Space Life Sciences, Munich, Germany, Sep. 10-14, 2012. (Oral presentation)

    (12) Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge Zhang, Peng Shang, Airong Qian*. Response and adaptation of bone cells to simulated microgravity. 中国工程院分子医学前沿论坛暨中国细胞生物学学会细胞工程与转基因生物分会/陕西省细胞生物学学会2014年年会,中国,陕西咸阳,2014.11.7-9. (口头报告)

    (13)胡丽芳,苏佩红 李润芝 闫琨 商澎 骞爱荣*. MACF1促进前成骨细胞的迁移与分化. 中国空间科学学会空间生命专业委员会第二十届学术研讨会暨中国宇航学会航天医学工程与空间生物学专业委员会第四届学术研讨会,中国,广西南宁,2014.11.5-7. (墙报).