靳明亮


的个人主页 http://teacher.nwpu.edu.cn/jinmingliang

  被浏览次数:2459

基本信息 The basic information

靳明亮

生命学院

博士研究生毕业

博士

副教授

生物学

mljin@nwpu.edu.cn

工作经历 Work Experience

2011年7月至2011年8月,美国密苏里州立大学哥伦比亚分校,访问学者;

2011年7月至2013年6月,西北工业大学生命学院,航空宇航科学与技术博士后流动站,博士后;

2013年6月至2014年4月,西北工业大学生命学院,讲师;

2014年4月至今,西北工业大学生命学院,副教授

2015年9月至2017年2月,加拿大阿尔伯塔大学,访问学者;

2018年7月至2018年8月,加拿大阿尔伯塔大学,访问学者。

教育经历 Education Experience

2002.9-2006.6,南京农业大学动物科技学院,本科;

2006.9-2011.6,浙江大学动物科学学院,博士。 

教育教学 Education And Teaching

主讲课程:

本科生专业课《极端环境生理学》 (课程负责人)

本科生专业课《Microbiology》(全英文课程,负责人)

本科生专业基础课《遗传学》、《微生物学》

研究生专业选修课《生命科学导论》(课程负责人)

招生信息 Admission Information

硕士研究生招生专业:生物学(071000 ),生物工程(085238 )。 

荣誉获奖 Awards Information

2014-2015西北工业大学优秀教学成果一等奖;

2013-2014西北工业大学优秀教学成果二等奖。

科学研究 Scientific Research

主要研究方向:特殊环境肠道微生物与免疫,肠道微生物营养调控 。

主要研究内容:利用宏基因组学、代谢组学及转录组学等技术,开展模拟失重、高温等特殊环境以及糖脂代谢异常对肠道免疫功能的影响和营养调控研究,目的揭示肠道微生态中响应特殊环境及疾病的靶点微生物类群及调控机制。

主持的科研项目 

1. 国家自然科学基金青年基金:白术多糖对断奶应激诱导肠粘膜屏障损伤的调控作用及机制研究,2018-2020,项目编号:31702123

2. GF科技创新TQ项目:应用于******技术和装置研究,2018-2020,项目编号:17-****-01。

3. 陕西省自然科学基金面上项目:基于微生物区系研究模拟失重对肠黏膜屏障功能的影响,2017-2018,项目编号:2017JM3025

4. 中央高校基本科研业务费科研资助项目:白术多糖对模拟失重诱导肠黏膜屏障功能障碍的调控作用及机制研究,2017-2018,项目编号:3102017zy055。

5. 中国博士后科学基金特别资助项目:基于Toll样受体通路研究模拟失重对肠道免疫功能的影响,2013-2014,项目编号:2012T50821。

6. International Foundation for Science:Preparation, structural characterization and antiviral activities of sulfated polysaccharides from Astragalus membranaceus,2012-2014,项目编号:F/5206-1 

7. 中国博士后科学基金面上项目:模拟微重力环境下灵芝多糖硫酸酯化衍生物对肠道免疫功能的调控及其机理研究,2011-2013,项目编号:2011M501481 

8. 中央高校基本科研业务费科研资助项目:肠道微生态在模拟失重诱导肠黏膜损伤中的作用及机制研究,2014-2016,项目编号:3102014JKY15001。

学术成果 Academic Achievements

截止2018年7月,在Journal of Allergy and Clinical Immunology,Carbohydrate Polymers等期刊发表SCI论文30多篇(其中以第一作者及通讯作者发表SCI论文13篇,影响因子IF5合计47),被引用780余次(Google Scholar),H-index=12。 

发表学术论文:

[1]. Jin, M.L.,Zhang, H., Zhao, K., Xu, C.L., Shao, D. Y., Huang, Q.S., Shi, J.L., Yang, H. Responses of intestinal mucosal barrier functions of rats to simulated weightlessness. Frontiers in Physiology. 2018, 9: 729. 

[2]. Jin, M.L., Zhu, Y.M., Shao, D.Y., Zhao, K., Xu, C.L., Li, Q., Yang, H., Huang, Q.S., Shi, J.L. Effects of polysaccharide from mycelia of Ganoderma lucidumon intestinal barrier functions of rats. International Journal of Biological Macromolecules. 2017, 94: 1-9.

[3]. Xu, C.L, Guo, Y., Qiao, X.J., Shang, X.Y., Niu, W.N., Jin, M.L. Design, recombinant fusion expression and 1 biological evaluation of vasoactive intestinal peptide 2 analogue as novel antimicrobial agent. Molecules. 2017, 22: 1963. (Co-corresponding Author)

[4]. Zhao, K., Jin, M.L., Chen, Q., Zheng, P.S. Polysaccharides produced by Enterobacter cloacaeinduce apoptosis in cervical cancer cells. International Journal of Biological Macromolecules. 2015, 72: 960-964. (Co-first Author)

[5]. Jin, M.L., Wang, Y.M., Huang, M., Lu, Z.Q., Wang, Y.Z. Sulphation can enhance the antioxidant activity of polysaccharides produced by Enterobacter cloacaeZ0206. Carbohydrate Polymers. 2014, 99: 624-629.

[6]. Jin, M.L., Zhao, K., Huang, Q.S., Shang, P. Structural features and biological activities of the polysaccharides from Astragalus membranaceusInternational Journal of Biological Macromolecules. 2014, 64: 257-266.

[7]. Jin, M.L., Huang, Q.S., Zhao, K., Shang, P. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarumL. International Journal of Biological Macromolecules. 2013, 54: 16-23.

[8]. Jin, M.L., Zhao, K., Huang, Q.S., Shang, P. Preparation, structure and biological activities of exopolysaccharides produced by Enterobacter cloacaeAsian Journal of Chemistry. 2013, 25: 9101-9104.

[9]. Jin, M.L., Zhao, K., Huang, Q.S., Xu, C.L., Shang, P. Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis(Oliv.) Diels: A review. Carbohydrate Polymers. 2012, 89: 713-722.

[10].Jin, M.L., Lu, Z.Q., Huang, M., Wang, Y.M., Wang, Y.Z. Effect of Se-enriched polysaccharides produced by Enterobacter cloacaeZ0206 on alloxan-induced diabetic mice. International Journal of Biological Macromolecules. 2012, 50: 348-352.

[11].Jin, M.L., Lu, Z.Q., Huang, M., Wang, Y.M., Wang, Y.Z. Sulfated modification and antioxidant activity of exopolysaccahrides produced by Enterobacter cloacaeZ0206. International Journal of Biological Macromolecules. 2011, 48: 607-612.

[12].Jin, M.L., Wang, Y.M., Huang, M., Lu, Z.Q., Wang, Y.Z. Optimization of culture medium for exo-polysaccharide production by Enterobacter cloacaeZ0206 using response surface methodology. Asian Journal of Chemistry. 2011, 23: 3799-3802.

[13].Jin, M.L., Wang, Y.M., Xu, C.L., Lu, Z.Q., Huang, M., Wang, Y.Z. Preparation and biological activities of an exopolysaccharide produced by Enterobacter cloacaeZ0206. Carbohydrate Polymers. 2010, 81: 607-611.

[14].Arrieta, M.C., Arevalo, A., Stiemsma, L., Dimitriu, P., Chico, M.E., Loor, S., Vaca, M., Boutin, R.C.T., Morien, E., Jin, M., Turvey, S.E., Walter, J., Parfrey, L.W., Cooper, P.J., Finlay, B. Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a non-industrialized setting. Journal of Allergy and Clinical Immunology 2018, 142, 424-434.

[15].Nieves-Ramírez, M.E., Partida-Rodríguez, O., Laforest-Lapointe, I., Reynolds, L.A., Brown, E.M., Valdez-Salazar, A., Morán-Silva, P., Rojas-Velázquez, L., Morien, E., Parfrey, L.W., Jin, M., Walter, J., Torres, J., Arrieta, M.C., Ximénez-García, C., Finlay, B.B. Asymptomatic intestinal colonization with protist blastocystis is strongly associated with distinct microbiome ecological patterns. mSystems. 2018, 3: e00007-18.

[16].Yan, L., Zhao, H., Zhao, X., Xu, X., Di, Y., Jiang, C., Shi, J., Shao, D., Huang, Q., Yang, H.,Jin, M.Production of bioproducts by endophytic fungi: chemical ecology, biotechnological applications, bottlenecks, and solutions.  Applied Microbiology and Biotechnology. 2018, 105: 6279-6298.

[17].Riaz Rajoka, M.S., Jin, M., Zhao, H., Li, Q., Shao, D., Huang, Q., Shi, J. Impact of dietary compounds on cancer-related gut microbiota and microRNA. Applied Microbiology and Biotechnology. 2018, 102: 4291-4303.

[18].Riaz Rajok, M.S., Jin, M., Zhao, H., Li, Q., Shao, D., Jiang, C., Huang, Q., Yang, H., Shi, J., Hussain, N. Functional characterization and biotechnological potential of exopolysaccharide produced by Lactobacillus rhamnosusstrains isolated from human breast milk. LWT-Food Science and Technology. 2018, 89: 638-647.

[19].Riaz Rajoka, M.S., Zhao, H., Lu, Y., Lian, Z., Li, N., Hussain, N., Shao, D., Jin, M., Li, Q., Shi, J. Anticancer potential against cervix cancer (HeLa) cell line of probiotic Lactobacillus casei and Lactobacillus paracasei strains isolated from human breast milk. Food and Function. 2018, 23: 2705-2715.

[20].Zhao, X., Zhou, L., Riaz Rajoka, M.S., Yan, L., Jiang, C., Shao, D., Zhu, J., Shi, J., Huang, Q., Yang, H., Jin, M.Fungal silver nanoparticles: synthesis, application and challenges. Critical Reviews in Biotechnology. 2018, 38: 817-835.

[21].Deehan, E.C., Duar, R.M., Armet, A.M., Perez-Munoz, M.E., Jin, M., Walter, J. Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health. Microbiology Spectrum. 2017, 5(5): BAD-0019-2017.

[22].Li, J., Rajoka, W.S.R., Shao, D., Jiang, C., Jin, M., Huang, Q., Yang, H., Shi, J. Strategies to increase the efficacy of using gut microbiota for the modulation of obesity. Obesity Reviews. 2017, 18: 1260-1271.

[23].Riaz Rajoka, M.S., Shi, J., Zhu, J., Shao, D., Huang, Q., Yang, H., Jin, M.Capacity of lactic acid bacteria in immunity enhancement and cancer prevention. Applied Microbiology and Biotechnology. 2017, 101: 35-45.

[24].Shao, D., Yao, L., Riaz, M.S., Zhu, J., Shi, J., Jin, M., Huang, Q., Yang, H. Simulated microgravity affects some biological characteristics of Lactobacillus acidophilusApplied Microbiology and Biotechnology. 2017, 101: 3439-3449.

[25].Zhao, H., Shao, D., Jiang, C., Shi, J., Li, Q., Huang, Q., Rajok, M.S.R., Yang, H., Jin, M.Biological activity of lipopeptides from Bacillus. Applied Microbiology and Biotechnology. 2017, 101: 5951-5960.

[26].Li, Q., Zhang, Y., Shi, J.L., Wang, Y.L., Zhao, H.B., Shao, D.Y., Huang, Q.S., Yang, H., Jin, M.L.Mechanism and anticancer activity of the metabolites of the endophytic fungi Eucommia ulmoidesOliv. Anti-cancer Agents in Medicinal Chemistry. 2017, 17: 982-989.

[27].Shao, D., Wang, Y., Huang, Q., Shi, J., Yang, H., Pan, Z., Jin, M., Zhao, H., Xu, X. Cholesterol-lowering effects and mechanisms in view of bile acid pathway of resveratrol and resveratrol glucuronides. Journal of Food Science. 2016, 81: H2841-H2848.

[28].Lu, Y., Shao, D., Shi, J., Huang, Q., Yang, H., Jin, M.Strategies for enhancing resveratrol production and the expression of pathway enzymes. Applied Microbiology and Biotechnology. 2016, 100: 7407-7421.

[29].Xie, J.H., Tang, W., Jin, M.L., Li, J.E., Xie, M.Y. Recent advances in bioactive polysaccharides from Lycium barbarumL., Zizyphus jujubaMill, Plantagospp., and Morusspp.: Structures and functionalities. Food Hydrocolloid. 2016, 60: 148-160.

[30].Xie, J.H., Jin, M.L., Morris, G.A., Zha, X.Q., Chen, H.Q., Yi, Y., Li, J.E., Wang, Z.J., Gao, J., Nie, S.P., Shang, P., Xie, M.Y. Advances on bioactive polysaccharides from medicinal plants. Critical Reviews in Food Science and Nutrition. 2016, 56(S1): S60-S84.

[31].Yang, H., Tang, R.H., Li, J., Liu, Y.X., Ye, L.J., Shao, D.Y., Jin, M.L., Huang, Q.S., Shi, J.L. A new Ex Vivo method for effective expansion and activation of human natural killer cells for anti-tumor immunotherapy.Cell Biochemistry and Biophysics. 2015, 73: 723-729.

[32].Yang, H., Liu, Y.X., Tang, R.H., Shao, D.Y., Li, J., Ye, L.J., Jin, M.L., Huang, Q.S., Shi, J.L. Cell signaling in the interaction between pathogenic bacteria and immune cells. Frontiers in Bioscience-Landmark. 2015, 20: 1029-1035.

[33].Yang, H., Tang, R.H., Li, J., Li, J., Liu, Y.X., Ye, L.J., Shao, D.Y., Jin, M.L., Huang, Q.S., Shi, J.L. Changes of cytoskeleton affect T cell biological behaviors. Frontiers in Bioscience-Landmark. 2015, 20: 829-837.

[34].Yang, H., Li, J., Tang, R.H., Li, J., Liu, Y.X., Ye, L.J., Shao, D.Y., Jin, M.L., Huang, Q.S., Shi, J.L. The aspartyl (asparaginyl) beta-hydroxylase in carcinomas. Frontiers in Bioscience-Landmark. 2015, 20: 902-909.

[35].Huyan, T., Li, Q., Yang, H., Jin, M.L., Zhang, M.J., Ye, L.J., Li, J., Huang, Q.S., Yin, D.C. Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells. Carbohydrate Polymers. 2014, 101: 819-827.

[36].Lu, Z.Q., Jin, M.L., Huang, M., Wang, Y.M., Wang, Y.Z. Bioactivity of selenium-enriched exopolysaccharides produced by Enterobacter cloacaeZ0206 in broilers. Carbohydrate Polymers. 2013, 96: 131-136.

[37].Xu, C.L., Wang, Y.Z., Jin, M.L., Yang, X.Q. Preparation, characterization and immunomodulatory activity of selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacae Z0206. Bioresource Technology. 2009, 100: 2095-2097. 

 

发表会议论文:

[1]. Jin, M.L., Shang, P. Effects of simulated weightlessness on the intestinal mucosal barrier functions of rats. Proceeding of the 19th International Academy of Astronautics (IAA) Humans in Space. Jul. 2013. Cologne, Germany.

[2]. Jin, M.L., Wang, Y.M., Lu, Z.Q., Huang, M., Xu, C.L., Wang, Y.Z. Isolation, characterization and antioxidant activity of an exopolysaccharide produced by Enterobacter cloacae Z0206. Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting. Jul. 2010. Denver, USA.

[3]. Jin, M.L., Wang, Y.Z., Yang, X.Q., Xu, C.L., Lu, Z.Q. Protective effect of polysaccharide produced by Enterobacter cloacae Z0206 on cyclophosphamide-induced suppression of immune functions in mice. Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting. Jul. 2009. Montreal, Canada.

[4]. Jin, M.L., Wang, Y.Z., Xu, C.L., Yang, X.Q. Effect of enriched-Selenium exopolysaccharide and exopolysaccharide produced by Enterobacter cloacae Z0206 on immune function of immunosuppressed mice. Proceeding of the 13th Animal Science Congress of the Asian-Australasian Association of Animal Production Societies. Sep. 2008. Hanoi, Vietnam.


参编著作:

[1]. Deehan, E.C., Duar, R.M., Armet, A.M., Perez-Munoz, M.E., Jin, M., Walter, J. Chapter 20: Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health. Bugs as Drugs: Therapeutic Microbes for the Prevention and Treatment of Disease. ASM Press, 2018. 

社会兼职 Social Appointments

中国微生物学会会员、中国空间科学学会会员, 美国动物科学学会会员。