施建宇

的个人主页 http://teacher.nwpu.edu.cn/shijianyu

基本信息 The basic information

施建宇

生命学院

博士研究生毕业

工学博士

副教授

生物医学工程

jianyushi@nwpu.edu.cn

029-88460254

工作经历 Work Experience

2007年至2009年任西北工业大学计算机学院博士后,2009年晋升为副教授教授,2012年1月-2014年6月 参与人社部“香江学者”计划 (香港大学计算机系),现为生命学院生物医学工程系副教授。 

教育经历 Education Experience

1999年毕业于西北工业大学飞机设计专业,1999年获飞行器设计硕士学位,2007年获模式识别与智能系统博士学位。 

教育教学 Education And Teaching

研究方向:

蛋白质序列与结构分类

药物与蛋白质相互作用预测 

主讲课程:

本科生专业课《生物信息学》

研究生专业课《生物信息学》 

荣誉获奖 Awards Information

获奖

1. 2017年,国防技术发明奖(一等奖),目标监测图像处理关键技术及应用系统,排名第5,颁发单位:工业和信息化部

2. 2010年,陕西省第十一届自然科学优秀学术论文奖(二等奖),排名第1,颁发单位:陕西省人民政府

3. 2009年,陕西省第十届自然科学优秀学术论文奖(一等奖), 排名第5 ,颁发单位:陕西省人民政府

  

科学研究 Scientific Research

  1. 2019.01-2022.12国家自然科学基金(面上项目61872297 ),复杂类型药物相互作用鉴别方法研究,62万 
  2. 西北工业大学校内基础研究基金(自由探索,3102015ZY081),药物-靶蛋白相互作用预测,15万,
  3. 2013.01-2014.09,香港大学小项目基金(201209176053),Structural Classification of Protein Domain 7.7万港币
  4. 2012.01-2014.01,博士后科学基金特别资助(201104682),基于图像的蛋白质结构分类,10
  5. 2012.11-2014.11,博士后科学基金(2012M521803),蛋白质超家族公共结构核心无监督检测方法研究, 5万,
  6. 2011.01-2013.12,西北工业大学基础研究基金(JC201164),基于图像的蛋白结构分类,15
 

学术成果 Academic Achievements

近期发表和录用论文(第一作者或通讯作者)

[1] Jian-Yu Shi*, Jia-Xin Li, Bo-Lin Chen, Yong Zhang. Inferring Interactions between Novel Drugs and Novel Targets via Instance-Neighborhood-Based Models. Current Protein & Peptide Science,2018, 19(5):488-497.( SCI中科院三区,影响因子2.576)

[2] Hui Yu, Kui-Tao Mao, Jian-Yu Shi*, Hua Huang, Zhi Chen, Kai Dong and Siu-Ming Yiu. Predicting and understanding comprehensive drug-drug interactions via semi-nonnegative matrix factorization. BMC Systems Biology, 2018, 12 (S1)14 (SCI, 中科院二区, 影响因子2.303 )

[3] Jian-Yu Shi*, Hua Huang, Jia-Xin Li, Peng Lei, Yan-Ning Zhang, and Siu-Ming Yiu. Predicting Comprehensive Drug-Drug Interactions for New Drugs via Triple Matrix Factorization. IWBBIO 2017, Part I, LNBI 10208, pp. 1-10, 2017. (论文的扩展版本,已被BMC Bioinformatics录用,SCI中科院二区,影响因子2.448)

[4] Jian-Yu Shi*, Hua Huang, Yan-Ning Zhang, Jiang-Bo Cao, Siu-Ming Yiu. BMCMDA: a novel model for predicting human microbe-disease associations via binary matrix completion. BMC Bioinformatics, 2018, 19(Suppl 9):2274 (SCI中科院二区,影响因子2.448)

[5] Jian-Yu Shi*, Xue-qun Shang, Ke Gao, Shao-Wu Zhang, Siu-Ming Yiu. An Integrated Local Classification Model of Predicting Drug-Drug Interactions via Dempster-Shafer Theory of Evidence. Scientific Reports. 2018, 8(1):11829 (SCI中科院二区,影响因子4.122)

[6] Jian-Yu Shi*, Hua Huang, Yan-Ning Zhang, Siu-Ming Yiu. Predicting binary, discrete and continued lncRNA-disease associations via a unified framework based on graph regression. BMC Medical Genomics 2017, 10(S4):65 (SCI中科院三区,影响因子2.848)

[7] Jian-Yu Shi*, Lia-Xin Li, Ke Gao, Peng Lei and Siu-Ming Yiu. Predicting combinative drug pairs towards realistic screening via integrating heterogeneous features. BMC Bioinformatics. 2017, 18(S12):409, SCI中科院二区,影响因子2.448).

[8] Hui-Meng Lu*, Xiao-Li Lu, Jia-Hui Zhai, Ren-Bin Zhou, Yan-Li Qin, Jing-Di Li, Chen-Yan Zhang, Jian-Yu Shi*. Ligand-binding characterization of simulated β-adrenergic-like octopamine receptor in Schistocerca gregaria via progressive structure simulation. Journal of Molecular Graphics & Modelling, 2017 , 77 :25 (SCI中科院三区,影响因子1.754)

[9] Jian-Yu Shi*, Jia-Xin Li, Hui-Meng Lu, Predicting existing targets for new drugs base on strategies for missing interactions. BMC Bioinformatics, 2016,Aug 31, 17 (S8):282. (SCI中科院二区,影响因子2.576)

[10] Jian-Yu Shi, Siu-Ming. Yiu, Yiming Li, Henry C. M. Leung and Francis Y. L. Chin*, Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super-Target Clustering. METHODS. 2015, 83:98-104.(SCI中科院二区,影响因子3.802)

[11] Jian-Yu Shi*, Zun Liu, Hui Yu, Yong-Jun Li. Predicting Drug-Target Interactions via Within-Score and Between-Score. BioMed Research International 2015 Article ID 350983, 9 pages(SCI中科院三区,影响因子2.476).

[12] Jian-Yu Shi*, Siu-Ming Yiu. SRP: A Concise Non-parametric Similarity-Rank-based Model for Predicting Drug-Target Interactions. IWBNA in conjunction with BIBM 2015. 1636-1641(论文录用率19%)

[13] Jian-Yu Shi*, Jia-Xin Li, Hui-Meng Lu, Yong Zhang. Predicting Drug-Target Interactions between New Drugs and New Targets via Pairwise K-Nearest Neighbor and Automatic Similarity Selection. IScIDE 2015, Part II, LNCS 9243, pp. 477–486, 2015. (EI)

[14] Jian-Yu Shi, Siu-Ming Yiu, Yan-Ning Zhang, Francis Yuk-Lun Chin*. Effective moment feature vectors for protein domain structures. PLoS One. 2013, 8(12):e83788 . (SCI中科院三区,影响因子2.806)

其他论文

[15] Zhou RB, Lu HM, Liu J, Shi JY, Zhu J, Lu QQ, Yin DC*.A Systematic Analysis of the Structures of Heterologously Expressed Proteins and Those from Their Native Hosts in the RCSB PDB Archive. PLoS One. 2016 Aug 12;11(8):e0161254. (SCI,影响因子3.057)

[16] Yong Zhang, Joseph WT Chan, Francis YL Chin, Hing-Fung Ting, Deshi Ye*, Feng Zhang, Jianyu Shi. Constrained pairwise and center-star sequences alignment problems. J. Comb Optim, 2015, 1-16 (SCI,影响因子1.080).

[17] Guo Y. Z., Sun L. H., Oberthuer D., Zhang C. Y., Shi J. Y., Di J. L., Zhang B. L., Cao H. L., Liu Y. M., Li J., Wang Q., Huang H. H., Liu J., Schulz J. M., Zhang Q. Y., Zhao J. L.*, Betzel C.*, He J. L.*, Yin D. C.*, Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality, Scientific Reports, 4, 7308, Dec. 2014. (SCI二区,影响因子5.228)

[18] Guo Y. Z., Liu Y. M., Yin D. C.*, He J., Zhang C. Y., Cao H. L., Hou H., Ma W., Guo W. H., Shi J. Y., Cui C., Wang Z., Shang P., Surface treatment by oxidizing the plates can alter the response of protein crystallization, J. Appl. Cryst. 47, 228–236, Feb 2014. (SCI,影响因子2.570)

[19] Rui-Qing Chen, Da-Chuan Yin*, Qin-Qin Lu, Jian-Yu Shi and Xiao-Liang Ma. Sensitivity of lysozyme crystallization to minute variations in concentration. Acta Cryst D. 2012: D68, 584-591.(SCI)

[20] Yun-Zhu Guo, Da-Chuan Yin*, Hui-Ling Cao, Jian-Yu Shi, et al. Evaporation rate of water as a function of magnetic field and field gradient. Int. J. Mol. Sci. 2012,13(12),16916-16928. (SCI,影响因子3.257)

团队信息 Team Information