徐春兰

的个人主页 http://teacher.nwpu.edu.cn/xuchunlan

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基本信息 The basic information

徐春兰

生命学院

博士研究生毕业

博士

副教授

生物学

clxu@nwpu.edu.cn

029-88460543

工作经历 Work Experience

2008-2010   西北工业大学生命学院 博士后

2010-2011   西北工业大学生命学院 讲师

2011-至今    西北工业大学生命学院副教授 

2014-2015   加州大学洛杉矶分校访问学者

教育经历 Education Experience

1998-2002年  华中农业大学  攻读学士学位

2003-2008年  浙江大学        攻读硕-博士学位 

教育教学 Education And Teaching

研究方向:

(1)神经肽介导的微生物-脑-肠轴对肠道屏障功能的调控机制

(2)动物源性防御肽-必需微量元素-益生菌类复合微生态制剂的研制

(3)低压低氧环境下的生物学效应及其防护研究 

主讲课程:

本科生专业基础课《生物化学》

本科生专业选修课《分子营养学》

研究生公共课《高级生物化学实验技术》

参与讲授课程:

本科生专业课《生物学概论》 

本科生实验课《生物化学实验》

本科生实验课《分子生物学实验》

研究生专业课《生命科学导论》

研究生专业课《生物技术与工程》

荣誉获奖 Awards Information

2011-2012年度西北工业大学本科生奖教金

2011-2012年度西北工业大学“优秀青年教师”

2013年“西北工业大学吴亚军优秀青年教师奖教金”(一等)

2013年“西北工业大学优秀班主任” 

2015-2016年西北工业大学先进女教职工工作者、“三八红旗手”

科学研究 Scientific Research

国家自然科学基金-面上项目(31672435

国家自然科学基金-青年项目(31001012

陕西省重点研发计划项目(2018NY-102)

陕西省科学技术研究发展计划项目2013K02-16

中国博士后特别资助基金(201003686

中国博士后科学基金(一等)(20080440195)、

中央高校基本科研业务费资助项目(3102015BJ(Ⅱ)MYZ29

西北工业大学基础研究基金(JC201278

西北工业大学科技创新基金(2008KJ02040 

学术成果 Academic Achievements

近年来的主要代表性论文如下:

1. Chunlan Xu* , Yu GuoLei QiaoLi MaYi-yi Cheng. Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized by Lactobaccillus casei ATCC 393. Carbohydrate Polymers. 2018, 195: 576-585.

2. Chunlan Xu* , Yu GuoLei QiaoLi MaYiyi Cheng, Alexandra Roman. Biogenic synthesis of novel functionalized selenium nanoparticles by Lactobacillus casei 393 and its protective effects on intestinal barrier dysfunction caused by Enterotoxigenic Escherichia coli K88. Frontiers in Microbiology. 2018, 9: 1129.

3. Chunlan Xu* , Yu GuoLei QiaoLi MaYiyi Cheng. Recombinant vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats. World Journal of Gastroenterology. 2018,24(6):706-715.

4. Chunlan Xu*Yu GuoXiangjin QiaoXiaoya ShangWeining NiuMingliang Jin*Design, recombinant fusion expression and biological evaluation of vasoactive intestinal peptide analogue as novel antimicrobial agent. Molecules. 2017, 22:1963.

5. Chunlan XuSally GhaliJiani Wanget al. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway. Scientific Reports. 2017, 7:16351

6. Chunlan Xu*, XJ Qiao, Y.F.Zhao, R.Sun, X.Y.Shang, W.N.Niu. Resveratrol ameliorates chronic high altitude exposure-induced oxidative stress and lipid metabolism alteration in rats. European Journal of Lipid Science and Technology. 2016, 118:612-621.

7. Chunlan Xu*Youming Wang; Rui SunXiangjin QiaoXiaoya ShangWeining NiuModulatory Effects of Vasoactive Intestinal Peptide on Intestinal Mucosal Immunity and Microbial Community of Weaned Piglets Challenged by an  Enterotoxigenic Escherichia coli (K88). PLos One. 2014, 9(8):e104183.

8. Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.NiuProtective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment. World Journal of Gastroenterology. 2014, 20(16): 4467-4838.

9. Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.Niu, Y. ChaoEffect of vitamin E supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment. Korean Journal of Physiology & Pharmacology. 2014,18:1-8.

10. Chunlan Xu*, C.Dong, C.C.Xu, T.T. Han, S.Bao, X.B.Gao. Effect of iron glycinate chelate on the expression of hypoxia-inducible factor and antioxidant status in rats exposed to high altitude hypoxia environment. Biological Trace Element Research. 2014, 162:142-152.

11. C.L.Xu*, Y.F. Zhao,X.Y.Shang, W.N.Niu. Effects of diet-derived rhizomes of Atractylodes macrocephala Koidz on growth performance and immune function in piglets. Journal of Animal and Feed Sciences. 2012, 21(2): 302-312.

12. C.L.Xu, C.G.Qin, R.J.Zhang, W.N.Niu, X.Y.Shang. Solid-phase synthesis and antibiotic activities of cyclodecapeptides on the scaffold of naturally occurring laterocidin. Bioorganic & Medicinal Chemistry Letters.2010, 20(1): 164-167. 

13. C.L.Xu, Y.Z.Wang, M.L.Jin, X.Q.Yang. Preparation, characterization and immunomodulatory activity of selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacae Z0206. Bioresource Technology. 2009, 100(6): 2095-2097. 

14. Jiani Wang, Sally Ghali, Chunlan Xu, et al. Ceragenin CSA13 reduces Clostridium difficile infection in mice by modulating the intestinal microbiome and metabolites. Gastroenterology. 2018, 154(6): 1737-1750.

15. Hon Wai Koon, Bowei Su, Chunlan Xu, et al. Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. American Journal of Physiology- Gastrointestinal and Liver Physiology. 2016, 311(4):G610-G623.


社会兼职 Social Appointments

陕西省药学会药物化学委员会委员,中国生物化学与分子生物学会会员