张瑞雪

的个人主页 http://teacher.nwpu.edu.cn/zhangruixue

  被浏览次数:2323

基本信息 The basic information

张瑞雪

生命学院

博士研究生毕业

哲学博士

副教授

zhangruixue@nwpu.edu.cn

综合介绍 General Introduction

 

张瑞雪教授 (ORCID iD iconorcid.org/0000-0002-9418-8125)于2016年获得加拿大多伦多大学药学博士学位,之后在多伦多大学药学院教授Prof. Xiao Yu (Shirley) Wu 课题组进行针对乳腺癌治疗的纳米医药设计和应用的博士后科研,2017年12月加入西北工业大学生命学院工作。张瑞雪教授科研方向主要基于脂质和聚合物的递药系统,具体包括:1)新型协同联合用药纳米递药系统的设计、表征以及在治疗多药耐药癌症的评价;2)  临床前纳米药物在体内宏观与微观代谢动力和生物分布的机制;3)口服药物制剂在增强药物吸收以及改善肠道环境的设计及应用。张瑞雪教授有近10年的双语(中文/英文)高等教学经验,被授予多伦多大学高等教育学证书。


教育经历 Education Experience

2003.09 - 2007.08  加拿大麦克马斯特大学,生命科学院,分子生物学专业 理学学士学位


2007.09 - 2009.08  加拿大麦克马斯特大学,医学院, 获医药科学专业 理学硕士学位


2009.09 - 2016.08  加拿大多伦多大学,药学院,获制药科学专业 博士学位

2016.09 - 2017.10  加拿大多伦多大学,药学院,博士后 



学术成果 Academic Achievements

#并列第一作者;*通讯作者;高被引论

2019年

Ting Huyan, Yongyong Du, Dandan Dong, Qi Li, Rui Xue Zhang, Jiancheng Yang, Zhouqi Yang, Jingbao Li*, Peng Shang*, Osteoclast-derived Exosomes Inhibit Osteogenic Differentiation Through Wnt/β-catenin Signaling Pathway in Simulated Microgravity Model, Acta Astronaut., 2019. 154: 140-152. (IF= 2.227) Link

2018年 

Zhigao Wang#, Rui Xue Zhang#, Tian Zhang, Chunsheng He, Rong He, Xingrong Ju*, Xiao Yu Wu*, In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer, ACS Appl. Mater. Interfaces, 2018. 10(48): 41056-41069. (IF=8.097) Link

Rui Xue Zhang, Jason Li,Tian Zhang,  Mohammad A. Amini, Chunsheng He, Brian Lu, Taksim Ahmed,  HoYin Lip, Andrew M. Rauth, Xiao Yu Wu*, Importance of Integrating Nanotechnology with Pharmacology and Physiology for Innovative Drug Delivery and Therapy – An Illustration with Firsthand Examples, Acta. Pharmacol. Sin., 2018.39: 825-844. (IF=3.562) Link

2017年

Rui Xue Zhang#, Lily Yi Li#, Jason Li, Zhengsong Xu, Azhar Z. Abbasi, Lucy Lin, Mohammad A. Amini, Weiyu Weng, Yu Sun, Andrew M. Rauth, Xiao Yu Wu*, Coordinating Bio-Interaction and Bio-Reaction of a Nanocarrier Material and an Anticancer Drug to Overcome Membrane Rigidity and Target Mitochondria in Multidrug-Resistant Cancer Cells, Adv. Funct. Mater., 2017, 27(39): 1700804-1700816. (IF =13.325) Link

Rui Xue Zhang, Taksim Ahmed, Lily Yi Li, Jason Li, Azhar Z. Abbasi, Xiao Yu Wu*, Design of Nanocarriers for Nanoscale Drug Delivery to Enhance Cancer Treatment Using Hybrid Polymer and Lipid Building Blocks, Nanoscale, 2017, 9: 1334-1355. (IF =7.233) Link

Rui Xue Zhang, Tian Zhang, King Chen, Ji Cheng, Pairs Lai, Andrew M. Rauth, K. Sandy Pang, Xiao Yu Wu*, Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-Bearing Mice, J. Vis. Exp., 2017. 128 (e56159): 1-13. (IF =1.184) Link


2016年  

Rui Xue Zhang, Ping Cai, Tian Zhang, King Chen, Jason Li, Ji Cheng, K. Sandy Pang, Hibret A. Adissu, Andrew M. Rauth, Xiao Yu Wu*, Polymer-Lipid Hybrid Nanoparticles Synchronize Pharmacokinetics of Co-encapsulated Doxorubicin-Mitomycin C and Enable Their Spatiotemporal Co-delivery and Local Bioavailability in Breast Tumor, Nanomedicine-Nanotechnol., 2016, 12: 1279-1290. (IF =6.5) Link

Rui Xue Zhang#, Ho Lun Wong#, Hui Yi Xue, June Young Eoh, Xiao Yu Wu*, Nanomedicine of Synergistic Drug Combinations for Cancer Therapy - Strategies and Perspectives, J. Control. Release., 2016, 240: 489-503. (IF =7.877) Link


2016年之前  

Adam J. Shuhendler#, Preethy Prasad#, Rui Xue Zhang#, Mohammad A. Amini, Mei Sun, Peter P. Liu, Robert G. Bristow, Andrew M. Rauth, Xiao Yu Wu*, Synergistic Nanoparticulate Drug Combination Overcomes Multidrug Resistance, Increases Efficacy, and Reduced Cardiotoxicity in a Non-immunocompromised Breast Tumor Model. Mol. Pharmaceut., 2014, 11: 2659-2674. (IF =4.556) Link

Jan D. Huizinga*, Ji-Hong Chen, Yong Fang Zhu, Andrew Pawelka, Ryan J. McGinn, Berj L. Bardakjian, Sean P. Parsons, Wolfgan A. Kunze, Richard You Wu, Premysl Bercik, Amir Khoshdel, Sifeng Chen, Sheng Yin, Qian Zhang, Yuanjie Yu, Qingmin Gao, Kongling Li, Xinghai Hu, Natalia Zarate, Phillip Collins, Marc Pistilli, Junling Ma, Rui Xue Zhang, David Chen, The Origin of Segmentation Motor Activity in the Intestine, Nat. Commun., 2014, 5: 3326-3337. (IF =12.353) Link

Rui Xue Zhang, Xuan Yu Wang, David Chen, Jan D. Huizinga*, Role of Interstitial Cells of Cajal in the Generation and Modulation of Motor Activity Induced by Cholinergic Neurotransmission in the Stomach, Neurogastroent. Motil., 2011, 23: e356-371. (IF =3.842) Link


教育教学 Education And Teaching

招生信息 Admission Information

荣誉获奖 Awards Information