董凯


的个人主页 http://teacher.nwpu.edu.cn/2016010236

基本信息 The basic information

董凯

生命学院

博士研究生毕业

医学博士

讲师(高校)

药学-药剂学

工作经历 Work Experience

2016.12-西北工业大学 生命学院 讲师

2019.06 西北工业大学 生命学院 讲师 硕士生导师

 

Dec 2016, lecturer, School of Life Sciences, Northwestern Polytechnical University.

June 2019, lecturer, Master's Supervisor, School of Life Sciences, Northwestern Polytechnical University.


教育经历 Education Experience

◆ 2013-2016 西安交通大学医学部 药物分析学  博士

◆ 2011-2013 西安交通大学医学部 药剂学         硕士

◆ 2006-2010 陕西中医药大学药学院 中药学     学士

 

◇ 2013-2016 PhD of Pharmaceutical Analysis, Xi’an Jiaotong University Health science center

◇ 2011-2013 Master in Pharmaceutics, Xi’an Jiaotong University Health science center

◇ 2006-2010 Bachelor in Traditional Chinese Medicine, College of Pharmacy, Shaanxi University of Chinese Medicine


教育教学 Education And Teaching

本科生课程:

《植物学》

《基因工程》

《文献检索与论文写作》

  研究生课程:

《临床药物代谢动力学》

 

Undergraduate Courses:

《Botany》

《Genetic Engineering》

《Literature Retrieval and Paper Writing》

 ◇ Graduate Courses:

《Clinical Pharmacokinetics》


招生信息 Admission Information

硕士学位研究生招生专业:

083100 生物医学工程

0860 生物与医药

 

Recruit master students in Biomedical Engineering and Biology & Medicine.


科学研究 Scientific Research

研究方向

1. 纳米药物传递系统;

2. 细胞内源性因子检测与分析;

3. 超分子系统构建与应用

◇ Research Fields

1 .Nano drug delivery system;

2. Detection and analysis of endogenous factors in cells;

3. Construction and application of supramolecular systems

 

科研项目

1. 国家自然科学基金青年基金:81803491,双探针共载肿瘤渗透性纳米荧光检测系统的构建及其在乳腺癌PDT精准治疗中的应用,2019-2021;

2. 陕西省自然科学基金:2019JQ-320,肿瘤渗透性纳米检测系统在三阴性乳腺癌PDT精准治疗中的应用,2019-2020;

3. 中国博士后科学基金面上项目:2018M633584,肿瘤渗透性纳米检测系统对乳腺癌PDT治疗的指导研究,2018-2020;

4. 陕西省博士后科研资助项目:2018BSHQYXMZZ43,靶向EGFR智能纳米诊疗系统的构建及其在 TNBC精准治疗中的应用,2018-2020;

5. 中央高校基本科研业务费:3102019smxy002,多功能纳米序贯治疗系统对乳腺癌精准渗透及均质治疗研究,2019-2020;

6. 西北工业大学科研启动费资助项目:3102017OQD043,氧化还原响应性纳米胶束的构建及其在多药耐药肿瘤中的应用研究,2017-2018。

◇ Fundings

1. National Natural Science Foundation of China (No.81803491), 2019-2021;

2. Natural Science Foundation of Shaanxi Province (No.2019JQ-320), 2019-2020;

3. China Postdoctoral Science Foundation (No.2018M633584), 2018-2020;

4. Postdoctoral Science Foundation of Shaanxi Province (No.2018BSHQYXMZZ43), 2019-2020;

5. Fundamental Research Funds for the Central Universities (No. 3102019smxy002), 2019-2020;

6. Fundamental Research Funds for the Central Universities (No. 3102017OQD043), 2017-2018



学术成果 Academic Achievements

◆ 发表SCI论文20余篇,申请及授权国家发明专利9项。代表性论文:

[1]      Dong K, Lei QY, Guo RH, Wu XL, Zhang YN, Cui N, Shi JY, Lu TL*. Regulating intracellular ROS signal by a dual pH/reducing-responsive nanogels system promotes tumor cell apoptosis. International Journal of Nanomedicine, 2019, 14: 5713-5728.

[2]      Dong K, Lei QY, Qi HF, Zhang YN, Cui N, Wu XL, Xie L, Yan XC, Lu TL*. Amplification of Oxidative Stress in MCF-7 Cells by a Novel pH-Responsive Amphiphilic Micellar System Enhances Anticancer Therapy. Molecular Pharmaceutics, 2019, 16 (2): 689-700.

[3]      Dong K, Yang CR, Yan Y, Wang PC, Sun Y, Wang K, Lu TL, Chen Q, Zhang YN, Xing JF*, Dong YL*. Investigation of the intracellular oxidative stress amplification, safety and anti-tumor effect of a kind of novel redox-responsive micelle. Journal of Materials Chemistry B, 2018, 6(7): 1105-1117.

[4]      Dong K, Zhang HF, Yan Y, Sun JY, Dong YL, Wang K, Zhang L, Shi XP, Xing JF*. Improvement of side-effects and treatment on the experimental colitis in mice of a resin microcapsule loading hydrocortisone sodium succinate. Drug Development and Industrial Pharmacy, 2017, 43(3): 448-457.

[5]      Dong K, Yan Y, Wang PC, Shi XP, Zhang L, Wang K, Xing JF*, Dong YL*. Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance. International Journal of Nanomedicine, 2016, 11: 5109-5123.

[6]      Dong K, Zeng AG, Wang ML, Dong YL, Wang K, Guo CN, Yan Y, Zhang L, Shi XP, Xing JF*. In vitro and in vivo study of a colon-targeted resin microcapsule loading a novel prodrug, 3, 4, 5-tributyryl shikimic acid. RSC Advances, 2016, 6: 16882-16890.

[7]      Dong K, Dong YL, You CY, Xu W, Huang XY, Yan Y, Zhang L, Wang K, Xing JF*. Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel. Drug Delivery, 2016, 23(1): 174-184.

[8]      Dong K, Dong LY, You CY, Xu W, Huang XY, Yan Y, Zhang L, Wang K*, Xing JF*. Assessment of the safety, targeting, and distribution characteristics of a novel pH-sensitive hydrogel. Colloid and Surface B-Biointerfaces, 2014, 123: 965-973.

[9]      Dong K, Xu W, You CY, Xing JF, Zhang JY, Gao Y, Wang K*. Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization. International Journal of Polymeric Materials and Polymeric Biomaterials, 2013, 62(14): 726-732.

[10]   Zeng AG#, Dong K #, Wang ML, Sun JY, Dong YL, Wang K, Guo CN, Yan Y, Zhang L, Shi XP, Xing JF*. Investigation of the colon-targeting, improvement on the side-effects and therapy on the experimental colitis in mouse of a resin microcapsule loading dexamethasone sodium phosphate. Drug Delivery, 2016, 23(6): 1992-2002.

[11]   Wang K#, Dong K #, Yan Y, Xu W, Zhang L, Zhao GL, Xing JF*. In vitro and in vivo study of a colon-targeting pH-sensitive hydrocortisone sodium succinate hydrogel. RSC Advances, 2015, 5(98): 80625-80633.

 

专利 patent

[1]    董凯,卢婷利,叶仙育,赵壮壮,pH响应性氧化石墨烯纳米片包覆介孔二氧化硅药物双载复合纳米粒子及制备方法,2019.08.09,中国,201910732152.3

[2]    张辰艳,刘杰,刘文婧,尹大川,杨长青,刘新利,董凯,赵士淇,靶向三阴性乳腺癌细胞penk基因的miR-506及其应用,2019.08.23,中国, 201910781018.2

[3]    武祥龙,张飞,刘浩,陈强,董凯,卢婷利,具有荧光成像和载药双功能的介孔二氧化硅纳米材料的制备方法,2018.10.25,中国,201811250870.9

[4]    王珂,邢建峰,许维,赵桂兰,闫岩,董凯,杨莹。一种结肠靶向型pH敏感水凝胶及其制备方法和应用,2017.06.06,中国,CN103919716B

[5]    王珂,邢建峰,游翠玉,许维,董凯。一种结肠靶向型pH敏感水凝胶及其制备方法和应用,2016.02.24,中国,CN103599064B

[6]    肖志强,邢建峰,董亚琳,郭辰宁,马丽,游翠玉,董凯,谢姣。一种化合物及其制备方法和抗溃疡性结肠炎用途,2015.06.17,中国,CN103483220B

[7]    董亚琳,邢建峰,郭辰宁,马丽,孙金钥,董凯,游翠玉,谢姣。一种化合物及其制备方法和抗溃疡性结肠炎用途,2015.04.29,中国,CN103483214B

[8]    麻纪斌,邢建峰,董亚琳,马丽,郭辰宁,董凯,游翠玉,谢姣。3,3’-偶氮双[6-(丁酰氧基)苯甲酸]及其制备方法和应用,2015.01.07,中国,CN103333084B

[9]    王珂,邢建峰,董凯,许维。一种高分子透皮吸收促进剂及其制备方法和应用,2014.11.05,中国,CN103100088B


社会兼职 Social Appointments

◆ 中国药学会会员

◆ 中国生物材料学会会员

◆ 陕西省药学会会员

◆ 陕西省天然药物学会会员

 

Member of the Chinese Pharmaceutical Association

◇ Member of China Biomaterials Society

◇ Member of Shaanxi Pharmaceutical Association

Member of Shaanxi Natural Medicine Society