李谧


的个人主页 http://teacher.nwpu.edu.cn/8C0BD684C64554F6E053640A280A3899

  被浏览次数:3294

基本信息 The basic information

李谧

医学研究院

博士研究生毕业

理学博士

副教授

工作经历 Work Experience

2019年7月至今  西北工业大学  副教授

教育经历 Education Experience

2004 8 月-2009 7 月:博士(直博),专业:神经生物学,学校:北京大学

1999 8 月-2004 7 月:本科,专业:基础医学,学校:北京大学


招生信息 Admission Information

硕士研究生:神经药理学、神经生物学

*欢迎具有生物学、药学及医学等背景的同学报考研究生!


科学研究 Scientific Research

多年来一直从事衰老的机制和阿茨海默症的发病机制的探索,和阿茨海默症有效药物新靶点的研发。文章发表在The journal of experimantal medicine和Neurobiolgy of aging等杂志;并在Molecular biology杂志担任同行审稿人。

学术成果 Academic Achievements

1.             Sun L, Liu X, Li X, Li M. Photosensitive inhibition of the GABA system in vitro. Sci Rep 2020, 10(1): 3133.

2.             Hullinger R, Li M, Wang J, Peng Y, Dowell JA, Bomba-Warczak E, Mitchell HA, Burger C, Chapman ER, Denu JM, Li L, Puglielli L. Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation. The Journal of experimental medicine 2016, 213(7): 1267-1284.

3.             Li M, Pehar M, Liu Y, Bhattacharyya A, Zhang SC, O'Riordan KJ, Burger C, D'Adamio L, Puglielli L. The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism. Neurobiol Aging 2015, 36(10): 2725-2736.

4.             Pehar M, Ko MH, Li M, Scrable H, Puglielli L. P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion. Aging cell 2014, 13(3): 449-456.

5.             Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L. Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer. J Neurosci 2014, 34(20): 6772-6789.