田镇豪


的个人主页 http://teacher.nwpu.edu.cn/2020030053

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基本信息 The basic information

田镇豪

生命学院

博士研究生毕业

工学博士

生物医学工程,化学工程与技术-应用化学

zhhtian@nwpu.edu.cn

工作经历 Work Experience

2020.10.16-至今    西北工业大学   博士后   合作导师:杨慧 教授

教育经历 Education Experience

2014.09-2020.06    大连理工大学   应用化学   工学博士(硕博连读)   


科学研究 Scientific Research

主要从事代谢酶及生物小分子荧光探针的开发,并将其应用于复杂生物体系中酶活性原位检测、相关疾病预诊、代谢酶抑制剂和高表达菌群的高通量筛选等诸多实用领域。同时致力于开发具备优良光动力/光热效率的新型小分子光敏剂/光热转换剂,并结合肿瘤内高表达酶或生物小分子的反应特性,实现肿瘤部位可激活响应,建立肿瘤诊疗一体化系统。

学术成果 Academic Achievements

1.  Zhenhao Tian, Lele Ding, Kun Li, Yunqing Song, Tongyi Dou, Jie Hou, Xiangge Tian, Lei Feng, Guangbo Ge*, Jingnan Cui*.Rational design of a  long-wavelength fluorescent probe for highly selective sensing of carboxylesterase 1 in living systems. Anal. Chem., 2019, 91, 5638-5645. (SCI一区Top, IF=6.785)

2.  Zhenhao Tian, Qingsong Yan, Lei Feng, Sa Deng, Chao Wang, Jingnan Cui, Chunjie Wang, Zhanjun Zhang, Tony D. James*, and Xiaochi Ma*. A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin. Chem. Commun., 2019, 55, 3951-3954. (SCI一区Top, IF=5.996)

3.  Zhenhao Tian Lei Feng, Lu Li, Xiangge Tian, Jingnan Cui, Houli Zhang, Chao Wang*, Huilian Huang, Baojing Zhang, Xiaochi Ma*. Visualized characterization of bacterial penicillin G acylase for the hydrolysis of β-lactams using an activatable NIR fluorescent probe. Sensor. Actuat. B-Chem., 2020, 310, 127872. (SCI一区Top, IF=7.100)

4.  Zhenhao Tian, Xiangge Tian, Lei Feng, Yan Tian, Xiaokui Huo, Baojing Zhang, Sa Deng, Xiaochi Ma* and Jingnan Cui*. A highly sensitive and selective two-photon fluorescent probe for glutathione S-transferase detection and imaging in living cells and tissues. J. Mater. Chem. B, 2019, 7, 4983-4989. (SCI二区, IF=5.344)

5.  Xiangge Tian, Zhenhao Tian, Yan Wang, Jie Hou, Lei Feng, Liang Song, Jingnan Cui, Xiaokui Huo, Xinyu Zhao, Dayong Zhou*, Chao Wang, Chengpeng Sun, Jing Ning, Xiaochi Ma*. A highly selective fluorescent probe for detecting glutathione transferases to reveal anticancer-activity sensitivity of cisplatin in cancer cells and tumor tissues. Sensor. Actuat. B-Chem., 2018, 277, 423-430. (Co-first author, SCI一区Top, IF=7.100)

6.  Jing Ning, Zhenhao Tian, Bo Wang, Guangbo Ge, Yue An, Jie Hou, Chao Wang, Xinyu Zhao, Yannan Li, Xiangge Tian, Zhenlong Yu, Xiaokui Huo, Chengpeng Sun, Lei Feng*, Jingnan Cui, and Xiaochi Ma*. A highly sensitive and selective two-photon fluorescent probe for real-time sensing of cytochrome P450 1A1 in living systems. Mater. Chem. Front., 2018, 2, 2013-2020. (Co-first author, IF=6.788)

7.  Yinzhu Jin, Zhenhao Tian, Xiangge Tian, Lei Feng, Jingnan Cui and Xiaochi Ma*. A highly selective fluorescent probe for real-time imaging of bacterial NAT2 and high-throughput screening of natural inhibitors for tuberculosis therapy. Mater. Chem. Front., 2019, 3, 145-150. (Co-first author, IF=6.788)

8.  Lele Ding, Zhenhao Tian, Jie Hou, Tongyi Dou, Qiang Jin, Dandan Wang, Liwei Zou, Yadi Zhu, Yunqing Song, Jingnan Cui*, Guangbo Ge*, Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe. Chinese Chem. Lett. 2019, 30, 558-562. (Co-first author, SCI二区, IF=4.632)