武双婵


的个人主页 http://teacher.nwpu.edu.cn/BEBC792873C951E3E053640A280A89C6

基本信息 The basic information

武双婵

医学研究院

博士研究生毕业

理学博士

副教授

药学

wuxx@nwpu.edu.cn

工作经历 Work Experience

明尼苏达大学-双城分校    博士后           2016年8月—2020年11月

西北工业大学          副教授         2021年4月--


教育经历 Education Experience

本科      武汉大学药学院            2007年9月--2011年6月

博士      武汉大学药学院            2011年9月--2016年6月


教育教学 Education And Teaching

药理学

招生信息 Admission Information

欢迎广大药学、基础医学、生物化学分子生物学背景的学子加入本课题组!

科学研究 Scientific Research

本课题组聚焦髓鞘形成细胞少突胶质细胞(中枢神经系统)和施旺细胞(外周神经系统)在神经损伤、神经退行性疾病下的功能变化,寻找有效的干预靶点。


主持承担科研项目:

中央高校基本科研业务费:基于PERK-eIF2α信号通路研究miR211对小鼠外周神经损伤的保护作用,G2021KY05104,2021年1月-2022年12月。

广东省区域联合基金:基于PERK-eIF2α信号通路研究miR211对小鼠脑卒中白质损伤的保护作用,2021A1515110801,2021年10月-2024年9月。

陕西省自然科学基金青年项目:基于施旺细胞非折叠蛋白反应研究Salubrinal对周围神经损伤的修复作用,2022JQ-910,2022年1月-2024年12月


学术成果 Academic Achievements

论文:

1.       Wu Shuangchan, Sarrabeth Stone,Yue Yue, Wensheng Lin, Endoplasmic reticulum associated degradation is required for maintaining the viability and function of adult mature Schwann cells. Glia. 2021, 69(2): 489-506. 

2.       Wu Shuangchan, Sarrabeth StoneKlaus-Armin Nave and Wensheng Lin. The Integrated UPR and ERAD in Oligodendrocytes Maintain Myelin Thickness in Adults by Regulating Myelin Protein Translation. Journal of Neuroscience. 2020, 40(43): 8214-8232. 

3.       Sarrabeth StoneWu Shuangchan (co-first)., Klaus-Armin Nave and Wensheng Lin. The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP. JCI insight. 2020, 5(5): e132364. 

4.       Wu Shuangchan, Yue Yue, A. Peng, L. Zhang, X. Cao, J. Xiang, S. Yin and D. Hong. Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats. Food & function. 2016, 7(6): 2624-2634. 

5.       Wu Shuangchan, Yue Yue,  Jian LiZhike LiXiaofei LiYunhui NiuJin XiangHong Ding.   Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in rats against cerebral ischemia. Molecular nutrition & food research. 2015, 59(10): 1930-1941. 

6.       Yue Yue,  Wu Shuangchan (co-first)Zhike LiJian LiXiaofei LiJin Xiang, Hong Ding.  Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enhanced intestinal barrier function. Food and function. 2015, 6(8): 2568-2577. 

7. Wu Shuangchan, Yue Y, Hui TianLi TaoYuting WangJin XiangShi Wang,  Hong Ding. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS[J]. Neuropharmacology. 2014, 83: 107-117. 

8. Wu Shuangchan, Yue Y, Hui TianZhike LiXiaofei LiWei He, Hong Ding. Carthamus red from CarthamustinctoriusL. exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway[J]. Journal of ethnopharmacology. 2013, 148(2)570–578. 

9. Lei Zhixin, Yue Yuan, Sarrabeth Stone, Wu Shuangchan; Wensheng Lin. NF-κB Activation Accounts for the Cytoprotective Effects of PERK Activation on Oligodendrocytes during EAE[J]. Journal of Neuroscience. 2020, 40(33): 6444-6456.

10. Sarrabeth Stone, Yue Yuan, Milos Stanojlovic, Wu Shuangchan, Gerard Karsenty,Wensheng Lin. Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis[J]. JCI Insight. 2019, 4(2): e124232-e124232.

11. Sarrabeth StoneWu ShuangchanStephanie JamisonWilaiwan DuroseJean Pierre PallaisWensheng Lin. Activating transcription factor 6α deficiency exacerbates oligodendrocyte death and myelin damage in immune‐mediated demyelinating diseases. Glia. 2018, 66(7): 1331-1345.

12. Tong Tao, Niu Yun-Hui, Yue Yuan, Wu Shuangchan, Ding Hong. Beneficial effects of anthocyanins from red cabbage (Brassica oleracea L. var. capitata L.) administration to prevent irinotecan-induced mucositis. Journal of Functional Foods. 2017, 32, 9-17. 

13. Lu Yuzhi, Wu Shuangchan, Yuan YueSi HeJun LiJun TangWei WangHai-Bing Zhou. Gossypol with hydrophobic linear esters exhibits enhanced antitumor activity as an inhibitor of antiapoptotic proteins. ACS medicinal chemistry letters. 2016, 7(12):1185-1190.

14Zhang Qianying,  Li Zhike, Wu Shuangchan, Hong Ding. Myricetin alleviates cuprizone induced behavioral dysfunction and demyelination in mice by Nrf2 pathway. Food and function. 2016, 7(10):4332-4342.

16. Yue Y, Wu Shuangchan, Hong Ding. Characterization and hepatoprotective effect of polysaccharides from Ziziphusjujuba Mill. var. spinosa (Bunge) Hu ex HF Chou sarcocarp[J]. Food and Chemical Toxicology. 2014, 74: 76-84.

17. Cao, X., Wu Shuangchan, et al., A high-throughput method for the simultaneous determination of multiple mycotoxins in human and laboratory animal biological fluids and tissues by PLE and HPLC–MS/MS. Journal of Chromatography B. 2013, 942-943:113-25.


专利:

1.   丁虹;武双婵;岳源,3-氨基-1-丙烷磺酸及其衍生物在制备脑卒中的药物中的应用。ZL 201210287615.8;

2.   丁虹;岳源;武双婵;李建;谢剑梅;王淇漫GAOH衍生物及其医药用途。ZL 20151 0003889.3;

3.   丁虹;武双婵;岳源甘氨酸-L-半胱氨酸-高牛磺酸三肽及其应用。ZL201210534121.5;

4.   丁虹;岳源;武双婵;杨阁 一种多糖组合物及其制备方法和用途。ZL 201210090100.9;

5.   丁虹;岳源;武双婵 一种壳聚糖与三肽组合物及其制备方法和应用。ZL 201310396559.6

6.   童静;丁虹;武双婵;李建;岳源 半胱氨酸?高牛磺酸二肽及其衍生物及其医药用途。ZL 201510569359.5




综合介绍 General Introduction