张悦周


的个人主页 http://teacher.nwpu.edu.cn/31D4B2A4E0FB4FD999DF492EF85066D3

  被浏览次数:2847

基本信息 The basic information

张悦周

柔性电子研究院

博士研究生毕业

哲学博士

副教授

化学-有机化学,药学-药剂学,计算机科学与技术-计算机应用技术

iamyzzhang@nwpu.edu.cn

工作经历 Work Experience

2019/01- 至今       副教授,西北工业大学柔性电子研究院

2016/12-2018/12     博士后,芬兰奥博学术大学

2015/06-2016/10      博士后,澳大利亚莫纳什大学

2015/03-2015/06      助理研究员,华中农业大学动物科技学院、动物医学院


教育经历 Education Experience

2009/12-2014/12    芬兰赫尔辛基大学博士

2008/03-2009/12    西北工业大学博士学习

2005/09-2008/03    西北工业大学硕士

1999/09-2003/07    西安工程大学学士


招生信息 Admission Information

欢迎对纳米医学、数据发掘方向的同学加入本团队,尤其是具有有机化学、计算化学、高分子、数据挖掘背景的博士、硕士、本科生加入本课题组。

科学研究 Scientific Research

本课题组在药物化学,化学信息学,纳米医学,微流体技术等领域开展研究工作。其代表性成果有编写计算机程序从数据库中挖掘磷酸根生物等排体,并将获得的结果运用于新靶标活性小分子化合物的合成中。建立白桦醇同系物抗利什曼原虫的定量构效关系并预测其生物靶标。通过高通量筛选技术发现针对捻转血矛线虫的先导化合物,优化其结构获得药效和安全性俱佳的候选药物分子。以DNA为基础的药物递送系统的构建及其生物医学应用。多孔二氧化硅和硅材料的制备并赋予其靶向功能,基于多种具有协同作用抗癌药的前药纳米颗粒的制备。使用微流体技术制备纳米颗粒,对装载了药物的多孔材料进行包裹实现载体的控制释放。合成石墨烯增强的水凝胶吸附以及微/纳滤膜去除水体中的重金属污染。

学术成果 Academic Achievements

近年来以第一作者或通讯作者发表Adv. Mater.、Adv. Funct. Mater.、J.Chem.Inf.Model、J Cheminform. 等国际著名学术期刊近20余篇,受邀为多家国际学术期刊的审稿人,并参与编写书籍章节3章。

代表性论文

1.    XiuzhenYang, Tengzhi Zhou, Renjian Deng, Zhenya Zhu,  Atif Saleem, Yuezhou Zhang*. Removal of Sb(III) by 3D-reduced graphene oxide/sodium alginate double-network composites from an aqueous batch and fixed bed system. Scientific Reports. 2021, 11:22374

2.    Yuezhou Zhang*, Huaguang Cui, Ruiqi Zhang, Hongbo Zhang* and Wei Huang*. Nanoparticulation of Prodrug into Medicines for Cancer Therapy. Advanced Science. 2021, 2101454

3.    Jingyan Gao, Xiaodong Ma, Lirong Zhang, Jiaqi Yan, Huaguang Cui, Yuezhou Zhang,* Dongqing Wang,* and Hongbo Zhang.* Self-Assembled Disulfide Bond Bearing Paclitaxel-Camptothecin Prodrug Nanoparticle for Lung Cancer Therapy. Pharmaceutics. 2020, 12(12), 1169

4.      Banfeng Ruan, Yuezhou Zhang, Solomon Tadesse, Sarah Preston, Aya C. Taki, Abdul Jabbar, Andreas Hofmann, Yaqing Jiao, Jose Garcia-Bustos, Jitendra Harjani, Thuy Giang Le, Swapna Varghese, Silvia Teguh, Yiyue Xie, Jephthah Odiba, Min Hu, Robin B. Gasser, Jonathan Baell*. Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus. European Journal of Medicinal Chemistry, 2020,190,112100

5.      Xiaodong Ma, Yuezhou Zhang,* and Korbinian Weisensee. Conducting Polymeric Nanocomposites with a Three-Dimensional Co-flow Microfluidics Platform, Micromachines, 2019,10(6), 383

6.      Xiaodong Ma, Ezgi zliseli, Yuezhou Zhang,* Guoqing Pan, Dongqing Wang,* and Hongbo Zhang.* Fabrication of Redox- Responsive Doxorubicin and Paclitaxel Prodrug Nanoparticles with Microfluidics for Selective Cancer Therapy, Biomaterials Science, 2019, 7(2):634-644

7.      Yuezhou Zhang, Henri Xhaard, Leo ghemtio*. Predictive classification models and targets identification for betulin derivatives as Leishmania donovani inhibitors. Journal of Cheminformatics. 2018, 10(1):40

8.      Yuezhou Zhang*, Jing Tu, Dongqing Wang, Haitao Zhu, Sajal Kumar Maity, Xiangmeng Qu, Bram Bogaert, Hao Pei, and Hongbo Zhang*. Programmable and Multifunctional DNA-Based Materials for Biomedical Applications. Advanced Materials. 2018, 30(24):1703658

9.      Yuezhou Zhang, Alexandre Borrel, Leo Ghemtio, Leslie Regad, Gustav Boije af Genns, Anne-Claude Camproux, Jari Yli-Kauhaluoma, Henri Xhaard*. Structural isosteres of phosphate groups in the Protein Data Bank. Journal of Chemical Information and Modeling, 2017,57(3), 499-516

10.      Xiuzhen Yang, Tengzhi Zhou, Bozhi Ren, Andrew Hursthouse, Yuezhou Zhang*. Removal of Mn (II) by Sodium Alginate/Graphene Oxide Composite Double-Network Hydrogel Beads from Aqueous Solutions. Scientific Reports. 2018, 8(1):10717

11.  Yuezhou Zhang, Mikael Jumppanen, Mirko M. Maksimainen, Samuli Auno, Zulfa Awol, Léo Ghemtio, Hari Venkannagari, Lari Lehti, Jari Yli-Kauhaluoma, Henri Xhaard, Gustav Boije af Genns*. Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. Bioorganic & Medicinal Chemistry, 2018, 26(8): 1588-1597

12.  Xiuzhen Yang, Yuezhou Zhang*, Liping Wang, Lili Cao, Kelin Li and Andrew Hursthouse. 2017, Preparation of a Thermally Modified Diatomite and a Removal Mechanism for 1-Naphthol from Solution. WATER, 2017, 9, (9), 651

13.  Y.Z. Zhang, G.C. Zhang, X.F. Sun, He, Z and M. Rajaratnam. Properties and Microstructure Study of Polyimide Foam Plastic. Cellular Polymers, 2010, 29(4):211-226

14.  Y.Z. Zhang, G.C. Zhang, Z. He, X.F. Sun, M. Rajaratnam. Visualization Study of Solid Poly (Ester-Amine Salt) Precursor Foaming Process. Cellular Polymers, 2010, 29(1):45-57

15.  Sari MattilaPirjo MerilahtiSarah WazirTania QuirinMirko M. MaksimainenYuezhou ZhangHenri XhaardLari LehtiTero Ahola. Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus ReplicationAntimicrobial Agents and Chemotherapy, 2021, 65(12):e0139821

16.  Feng Zhang, Yiran Zhang, LiKong, Huanhuan Luo, Yuezhou Zhang, ErmeiMkil, Jarno Salonen, Jouni T.Hirvonen, Yueqi Zhu, Yingsheng Cheng, Lianfu Deng, Hongbo Zhang*, Alexander Kros, Wenguo Cui*, Hélder A.Santos*. Multistage signal-interactive nanoparticles improve tumor targeting through efficient nanoparticle-cell communications. Cell Reports, 2021, 35, 109131

17.  Meiling Chen, Chenxi Peng, Yaoquan Su, Xue Chen, Yuezhou Zhang, Yu Wang, Juanjuan Peng, Qiang Sun, Xiaowang Liu,* and Wei Huang*. A General Strategy for Hollow Metal-Phytate Coordination Complex Micropolyhedra Enabled by Cation Exchange. Angewandte Chemie International Edition. 2020, 59, (47):20988-20995

18.  Minghua Yao, Ming Ma*, Hongbo Zhang, Yuezhou Zhang, Gang Wan, Jie Shen, Hangrong Chen*, Rong Wu*. Mesopore-Induced Aggregation of Cobalt Protoporphyrin for Photoacoustic Imaging and Antioxidant Protection of Stem Cell. Advanced Functional Materials, 2018, 1804497

19.  Yueqi Zhu#, Hongbo Zhang#, Yiran Zhang#, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng, Minghua Li*, Hélder A. Santos*, Wenguo Cui*. Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. Advanced Materials, 2018, 1805452

20.  Dongfei Liu*, Salvatore Cito, Yuezhou Zhang, Chang-Fang Wang, Tiina Sikanen and Hélder A. Santos*. A Versatile and Robust Microfluidic Platform towards High Throughput Synthesis of Homogeneous Nanoparticles with Tunable Properties. Advanced Materials. 2015, 27 (14): 2298-2304

21. Guicai Li*, Qi Han, Panjian Lu, Liling Zhang, Yuezhou Zhang, Shiyu Chen, Ping Zhang, Luzhong Zhang, Wenguo Cui, Hongkui Wang*, and Hongbo Zhang*. Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration. Research. 2020, 2603048

22. Xiao-Zhong Fan, Meng Liu, Ruiqi Zhang, Yuezhou Zhang, Songcan Wang, Haoxiong Nan, Yunhu Han*, Long Kong*. An odyssey of lithium metal anode in liquid lithium-sulfur batteries. Chinese Chemical Letters. https://doi.org/10.1016/j.cclet.2021.12.064.


专著

1. Yuezhou Zhang, Dongfei Liu, Hongbo Zhang and Hélder A. Santos*. chapter 7, Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery, Elsevier, 2019, 155-177

2. Yuezhou Zhang, Dhayakumar Rajan Prakash, Hongbo Zhang*. Nucleotide Aptamers as Theranostic Bionanomaterials, Theranostic Bionanomaterials, Elsevier, 2019, chapter 19, 423-446

3. Yuezhou Zhang, Luofeng Yu, Jianhong Zhang and Peng Li*. Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies. Polymeric Nanoparticulate Delivery Vehicles of Antimicrobials for Biofilm EradicationSpringer, 2020, Cham, 409-429

主持项目

陕西省科学技术厅,面上项目,2020JM-141,微流控制备高载药基因药物连续流制备及形成机制研究,2020-012021-123万元

陕西省科学技术厅,高校联合项目-重点项目,2020GXLH-Z-017,基于线粒体质量控制的蛋白标志物研究,2020-012023-1237万元

宁波市科技局,自然科学基金重点项目,202003N4006基于开源数据库的生物电子等排体网页服务器开发与应用研究,2020-11至2023-10,20




学术文献 Academic Literature