戴亮亮


的个人主页 http://teacher.nwpu.edu.cn/8DD05D57882C439588AD4BBED91B1785

  被浏览次数:17467

基本信息 The basic information

戴亮亮

医学研究院

博士研究生毕业

工学博士

副教授

院长助理

生物医学工程,材料科学与工程,药学

liangliangdai@nwpu.edu.cn

工作经历 Work Experience

2018/07-至今: 西北工业大学,医学研究院,副教授,硕士生导师

教育经历 Education Experience

2015/09-2018/06  重庆大学,生物医学工程专业,博士,导师:蔡开勇

2012/09-2015/06  重庆大学,生物学专业,硕士,导师:蔡开勇




招生信息 Admission Information

招生专业:

硕士研究生:药学、生物与医药

研究方向:

1)纳米药物递送系统的构建与抗肿瘤效应评价;

2)功能纳米控释系统肿瘤生物/免疫治疗的机制研究;

3)肿瘤微环境的分子调控及代谢干预策略。

*欢迎具有材料、化学、高分子、医学、生物学等背景的同学报考研究生!

科学研究 Scientific Research

戴亮亮教授(ORCID ID:0000-0002-2041-9357)一直从事构建生物功能性纳米药物递送系统肿瘤生物治疗的研究。近 5 年,在Nature Communicaiton, ACS Nano, Advanced Functional Materials, Advanced Science, Small, Biomaterials, Chemistry of Materials等本领域TOP期刊发表SCI论文40余篇。影响因子IF大于10的10篇,大于5的15篇,ESI高被引用论文及热点论文2篇,H指数23,SCI引用1500余次。在功能性纳米药物递送系统的构建与抗肿瘤疗效评价等研究领域具有一定的工作基础。2018年7月加入西北工业大学医学研究院工作。

 


荣誉获奖 Awards Information

2022年,入选西北工业大学人才培育支持计划

2021年,入选西北工业大学“翱翔新星”

2020年,入选陕西省高校科协青年人才托举计划


学术成果 Academic Achievements

代表性论文:

2022年

[17] Liangliang Dai, Mengjiao Yao, Zhenxiang Fu, etc al. Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2,3-dioxygenase-blockade tumor immunotherapy. Nature Communications. 2022, 13, 2688. (IF 17.694)

[16] Zhang Yuan, Jianshuang Wu, Zhenxiang Fu, Siyu Meng, Liangliang Dai*Kaiyong Cai. Polydopamine-mediated interfacial functionalization of implants for accelerating infected bone repair through light-activatable antibiosis and carbon monoxide gas regulated macrophage polarization. Advanced Functional Materials. 2022, 2200374. DOI: 10.1002/adfm.202200374. (IF 19.924)

2021年

[15] Liangliang Dai, Xiang Li, Xinmin Zheng, etc al. TGF-β blockade-improved chemo-immunotherapy with pH/ROS cascade-responsive micelle via tumor microenvironment remodeling. Biomaterials. 2021, 276, 121010. (IF 15.304)

[14] Xinmin Zheng, Pan Zhang, Zhenxiang Fu, Siyu Meng, Liangliang Dai*, Hui Yang*. Applications of nanomaterials in tissue engineering. RSC Adv. 2021, 11, 19041–19058. (IF 4.036)

[13] Zhang Yuan, Chuanchuan Lin, Liangliang Dai*, etc al. Near‐infrared light‐activatable dual‐action nanoparticle combats the established biofilms of methicillin‐resistant staphylococcus aureus and its accompanying inflammation. Small. 2021, 2007522. (IF 15.153)

2020年

[12] Liangliang Dai, Xiang Li, Mengjiao Yao, etc al. Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy. Biomaterials. 2020, 241, 119901. (IF 15.304

[11] Ke Li,  Lu Lu,  Chencheng Xue,  Ju Liu,  Ye He,  Jun Zhou,  Zengzilu Xia, Liangliang Dai*, Kaiyong Cai*. Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo. Nanoscale. 2020, 12, 130-144. (IF 8.307,HCP)

2019年

[10] Liangliang Dai, Xiang Li, Xianglong Duan, etc al. A pH/ROS cascade-responsive charge-reversal nanosystem with self-amplified drug release for synergistic oxidation-chemotherapy. Advanced Science. 2019, 6, 1801807. (IF 17.521)

[9] 戴亮亮,刘军杰,周骏,罗忠,蔡开勇。响应性纳米药物递送系统构建及肿瘤治疗研究[J],医用生物力学,2019年S1期

2018年

[8] Liangliang DaiKe Li, Menghuan Li, etc al. Size/Charge changeable acidity‐responsive micelleplex for photodynamic‐improved PD‐L1 immunotherapy with enhanced tumorpenetration. Advanced Functional Materials. 2018, 28, 1707249. (IF 19.924)

2017年

[7] Liangliang Dai, Ruisi Cai, Menghuan Li, etc al. Dual-targeted cascade-responsive prodrug micelle system for tumor therapy in vivo. Chemistry of Materials. 2017, 29, 6976-6992. (IF 10.508)

2016年

[6] Liangliang Dai, Yonglin Yu, Zhong Luo, etc al. Photosensitizer enhanced disassembly of amphiphilic micelle for ROS-response targeted tumor therapy in vivo. Biomaterials. 2016, 104, 1-17. (IF 15.304)

[5] Liangliang Dai, Junjie Liu, Zhong Luo, etc al. Tumor therapy: Targeted drug delivery systems. Journal of Materials Chemistry B. 2016, 4. 6758-6772. (IF 7.571

[4] Liangliang Dai, Qingfeng Zhang, Xinkun Shen, etc al. A pH-responsive nanocontainer based on hydrazone-bearing hollow silica nanoparticles for targeted tumor therapy. Journal of Materials Chemistry B. 2016, 4, 4594-4604.  (IF 7.571)

2015年以前

[3] Liangliang Dai, Qingfeng Zhang, Jinghua Li, etc al. Dendrimerlike mesoporous silica nanoparticles as pH-responsive nanocontainers for targeted drug delivery and bioimaging. ACS Applied Materials Interfaces. 2015, 7, 7357-7372. (IF 10.383)

[2] Liangliang Dai, Qingfeng Zhang, Hao Gu, etc al. Facile synthesis of yolk-shell silica nanoparticles for targeted tumor therapy. Journal of Materials Chemistry B. 2015, 3, 8303-8313. (IF 7.571, Hot Paper)

[1] Liangliang Dai, Jinghua Li, Beilu Zhang, etc al. Redox-responsive nanocarrier based on heparin end-capped mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo. Langmuir. 2014, 3, 7867-7877.  (IF 4.331)





代表性项目:

1)主持国家自然科学基金青年科学基金项目,2021.01-2023.12;

2)主持陕西省重点研发计划项目,2022.01-2023.12

3)主持陕西省高校科协青年人才托举计划,2021.01-2022.12;

4)主持陕西省自然科学基金青年项目,2019.01-2020.12;

5)主持中央高校基本科研业务费,2018.01-2020.12;