高永光

的个人主页 http://teacher.nwpu.edu.cn/gaoyongguang

基本信息 The basic information

高永光

生命学院

博士研究生毕业

理学博士

讲师(高校)

化学-有机化学,生物学-生物化学与分子生物学

工作经历 Work Experience

2008.07-2013.09 保诺科技(北京)有限公司  研究员

2016.07- 今   西北工业大学          教师


        July 2008 - Sep. 2013  Bioduro (Beijing) Technology Co., Ltd, Resercher.

        June 2016 - Present    Assistant Professor,  School of Life Sciences, Northwestern Polytechnical University.


教育经历 Education Experience

2013.09-2016.07 北京师范大学  有机化学  生物有机   博士  

2005.09-2008.07 浙江师范大学  有机化学  不对称合成  硕士    

2001.09-2005.07 唐山师范学院  化学教育  本科



        2013 - 2016   Beijing Normal University       Organic Chemistry     Ph.D.      

        2005 - 2008   Zhejiang Normal University    Organic Chemistry      MS         

        2001 - 2005   Tangshan Normal University   Chemistry                    BS


学术成果 Academic Achievements

发表论文(Journal Publications) :

1. Abdul Qadir, Yongguang Gao, Patil Suryaji, Ye Tian, Xiao Lin, Kai Dang, Shanfeng Jiang, Yu Li, Zhiping Miao  and Airong Qian. Non-Viral Delivery System and Targeted Bone Disease Therapy. International Journal of Molecular Sciences. 2019, 20, 565.

2. Yong-Guang Gao, Fen-Li Liu, Fu-Hua Lu, Uzair Alam, Quan Tang, Jia-Wei Huang, Zhong-Lin Lu. [12]aneN3-based single aliphatic chain modified cationic lipids as gene delivery vectors. Tetrahedron, 2019, 75, 658-664.

3. Yong-Guang Gao, Xiao Lin, Kai Dang, Shan-Feng Jiang, Ye Tian, Fen-Li Liu, Di-Jie Li, Yu Li, Zhi-Ping Miao and Ai-Rong Qian. Structure-activity relationship of novel low generation dendrimers for gene delivery. Organic & Biomolecular Chemistry, 2018, 16, 7833-7842.

4. Yong-Guang Gao, Uzair Alam, Ai-Xiang Ding, Quan Tang, Zheng-Li Tan, You-Di Shi, Zhong-Lin Lu, Ai-Rong Qian, [12]aneN3-based lipid with naphthalimide moiety for enhanced gene transfection efficiency. Bioorganic Chemistry, 2018, 79, 334-340.

5. Yong-Guang Gao, You-Di Shi, Ying Zhang, Jing Hu, Zhong-Lin Lu and Lan He, A naphthalimide-based [12]aneN3 compound as an effective and real-time fluorescence tracking non-viral gene vector. Chemical Communications, 2015, 51, 16695-16698.

6. Yong-Guang Gao, Ying Zhang, You-Di Shi, Zhong-Lin Lu, 1,8-naphthalimide-based [12]aneN3 compounds as selective and sensitive off-on probe for the sequential recognition of Cu2+ ions and ATP in aqueous solution and living cells. Talanta, 2016, 152, 438-446.

7. Yong-Guang Gao, Ying Zhang, You-Di Shi, Bing Gong, Zhong-Lin Lu, Fluorescent sensors based on [12]aneN3-modified BODIPY: discrimination of different biological thiols in aqueous solution and living cells. Bioorganic & Medicinal Chemistry, 2016, 24, 1550-1559.

8. Yong-Guang Gao, Uzair Alam, Quan Tang, You-Di Shi, Ying Zhang, Ruibing Wang, Zhong-Lin Lu, Functional lipids based on [12]aneN3 and naphthalimide as efficient non-viral gene vectors, Organic & Biomolecular Chemistry, 2016, 14, 6346-6354.

9. Yong-Guang Gao, Quan Tang, You-Di Shi, Ying Zhang, Ruibing Wang, Zhong-Lin Lu, A novel non-viral gene vector for hepatocyte-targeting and in-situ monitoring of DNA delivery in single cells, RSC Advances, 2016,6, 50053-50060.

10. Yongguang Gao, Weiyi Chen, Xinsheng Li, Dongcheng Xu. Palladium-catalyzed asymmetric allylic substitution using Phosphoramidite ligands with 1,1'-binaphthyl skeleton. Letters in Organic Chemistry, 2008, 5, 346-348;

11. Yong-guang Gao, Na Chen, Hua-jiang Wu and Xin-sheng. Li, Chiral copper-Schiff base catalyst for asymmetric Henry reaction. Russian Journal of Organic Chemistry. 2007, 43, 1754–1755.

12. Gao Yong-guang Mu Chu-chun, Li Xin-sheng, A new method synthesis and Crystal Structure of 2-phenyl-5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methano-8-quinolinol. Chinese Journal of Structural Chemistry. 2008, 27, 663-666.

13. Ying Zhang, Yong-Guang Gao,You-Di Shi, Lian-Qian Tan, Jessica S. Yue, Zhong-Lin Lu, [12]aneN3-based BODIPY as a selective and sensitive off–on sensor for the sequential recognition of Cu2+ ions and ADP. Chinese Chemical Letters, 2015, 26, 894–898.

14. Xiang-yan Meng, Yong-Guang Gao, Xin-Sheng Li, Dong-Cheng, Xu, Palladium- catalyzed Enantioselective Allylic Alkylation by New ChiralPyridine-Phosphite Ligands. Catalysis Communications, 2009, 10, 950-954

15. Wang, Qi-jun; Gao, Yong-guang, Meng, Xiang-yan, Li, Xin-sheng, Xu, Dong-cheng; Synthesis of new chiral N,P ligands and their application to allylation; Chinese Journal of Organic Chemistry, 2009, 29, 776-779

16. Xin-sheng Li, Li-chun Kong, Yong-guang Gao and Xiao-xia Wang; Enantioselective hydrogenation of olefins with axialchiral iridium QUINAP complex. Tetrahedron Letters, 2007, 48, 3915-3917.

17. Xinsheng Li, Qing Li, Xiaohua Wu, Yongguang Gao, Dongcheng Xua, and Lichun Kong. Enantioselective hydrogenation of olefins with planar chiral iridium ferrocenyloxazolinyl phosphine complexes. Tetrahedron: Asymmetry, 2007, 18, 629-634.

发明专利Patents):

  1. 高永光,骞爱荣,李郁,田野,党凯,姜山峰,罗晓庆,赵欣;酰胺键联接的萘酰亚胺多功能化合物的合成及应用,申请号:

  201910391102.3;

  2.骞爱荣,高永光,党凯,李郁,田野,姜山峰,罗晓庆,赵欣;酯键联接的萘酰亚胺大环多胺化合物的合成及应用,申请号:

  201910391101.9;

  3.骞爱荣,王雪,田野,高永光,李瑞云,裴佳伟,杨超飞,苏佩红,赵欣,罗晓庆,一种筛选miRNA调控剂的细胞模型及应

  用,申请号:201910504983.5;

4. 高永光,骞爱荣,党凯,田野,张文娟,姜山峰,赵欣,罗晓庆,多胺类阳离子脂质、转基因载体及其制备方法[P],申请号:201810358988.7;

5. 骞爱荣,高永光,党凯,田野,张文娟,姜山峰,赵欣,罗晓庆,树枝状分子类阳离子脂质、转基因载体及其制备方法[P],申请号:201810359941.2;

6. 高永光,骞爱荣,田野,李郁,党凯,姜山峰,罗晓庆,赵欣,杨超飞,萘酰亚胺修饰的树形高分子转基因载体、其制备方法及应用[P],申请号:201810641124.6;

7. 骞爱荣,高永光,蔺枭,胡丽芳,张文娟,罗晓庆,赵欣,李迪杰,骨靶向肽与萘酰亚胺修饰的树形高分子转基因载体、其制备方法及应用[P],申请号:201810620827.0

8. 卢忠林,高永光,唐权,史幼荻,张影,含有靶向基团及荧光基团的[12]aneN3类阳离子脂质、转基因载体及其制备方法[P],授权号:ZL201510919384.1.

9. 卢忠林,卢富华,高永光,张影,含大环多胺[12]aneN3的阳离子脂质、转基因载体及其制备方法[P],申请号:201610021249X.

10. Li Xin-sheng, Meng Xiang-yan, Gao Yong-guang, Xu Dong-cheng; Preparation and application of chiral N,P ligand compounds, Faming Zhuan li Shen qing Gong kai Shuo ming shu (2008), CN 101328190 A 20081224.

基金Fundings):

1. 主持陕西省基础研究计划项目(面上),荧光可视结构可控骨靶向非病毒基因载体的合成及性能研究(2019JM-230),2019.1- 2020.12,3.0 万元;

2. 主持中央高校基本科研业务费-西北工业大学新进教师科研启动费,可视化骨靶向非病毒基因载体的合成及对骨质疏松小鼠的治疗研究(G2016KY0307)2016.10 - 2018.9,15.0 万元。