蔺枭

的个人主页 http://teacher.nwpu.edu.cn/linxiao

基本信息 The basic information

蔺枭

生命学院

博士研究生毕业

理学博士

讲师(高校)

生物学-细胞生物学

linxiao@nwpu.edu.cn

工作经历 Work Experience

2016/07—至今,西北工业大学生命学院,助理教授 ,硕导


Jun 2016  Assistant Professor, School of Life Sciences, Northwestern Polytechnical University.

教育经历 Education Experience

2007/09-2011/07   中国农业大学食品科学与营养工程学院   工学学士

2011/09-2016/07   清华大学生命科学学院   理学博士 


2007-2011  Bechelor, College of Food Science & Nutritional Engineering, China Agriculture University.

2011-2016  PhD, School of Life sciences, Tsinghua University.

教育教学 Education And Teaching

本科生课程《生命科学导论》、《Genetics》

研究生课程《细胞培养技术》、《航天医学工程》、《细胞工程》


Undergraduate Courses:《Introduction to Life Science》、《Genetics》

Graduate Courses:《Cell Culture Technology》、《Aerospace Medical Engineering》、《Cell Engineering》



硕士研究生招生:具有生物学、医学、生物医学工程背景的本科生

Graduate enrollment:undergraduate students with a background in biology, medicine or biomedical engineering



科学研究 Scientific Research

国家自然科学基金面上项目,31170940,骨髓间充质干细胞界面行为的microRNA机理研究,2012/01-2015/12,60万元,已结题,第一参与人。 

国家自然基金青年基金,“MACF1/TCF4/miR-335信号轴在老年性骨质疏松症中的作用机制研究”(81700784),项目负责人。

中国博士后科研基金, “MACF1/miR-335调节MSC分化参与骨质疏松症发生机制研究”(2017M613196),项目负责人。

陕西省自然科学基金青年项目,“MACF1/TCF4/miR-335在MSC成骨分化中的作用”(2018JQ3049),项目负责人。

中央高校基本科研业务费,“一带一路”及校际重要合作伙伴科技合作种子基金(3102019ghxm012),项目负责人。

中央高校基本科研业务费,西北工业大学引进高层次人才科研启动费资助项目(3102017OQD041),项目负责人。



Fundings:

National Natural Science Foundation of China (Grant No. 31170940).

National Natural Science Foundation of China (Grant No. 81700784).

Chinese postdoctoral research foundation (Grant No. 2017M613196).

Shaanxi Natural Science Foundation (Grant No. 2018JQ3049).

Fundamental Research Funds for the Central Universities  (Grant No. 3102019ghxm012

Fundamental Research Funds for the Central Universities  (Grant No. 3102017OQD041

学术成果 Academic Achievements

学术论文:

1Xiao Lin#, Suryaji Patil#, Yongguang Gao*, Airong Qian*, The bone extracellular matrix in bone formation and regeneration, Frontiers in Pharmacology, 2020.

2Xiao Lin, Kewen Zhang, Daixu Wei, Ye Tian, Zhihao Chen, Airong Qian*. The impact of spaceflight and simulated microgravity on cell adhesion. International Journal of Molecular Sciences, 2020.  

3Wuxia Qiu#, Xiaoli Ma#, Xiao Lin#, Fan Zhao, Dijie Li, Zhihao Chen, Kewen Zhang, Ru Zhang, Pai Wang, Yunyun Xiao, Zhiping Miao, Kai Dang, Xiaoyang Wu, Airong Qian*, Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway, Journal of Cellular and Molecular Medicine, 2020.01,24(1):317-327. 

4Jianhua Ma#, Xiao Lin#, Chu Chen, Siyu Li, Shasha Zhang, Zhihao Chen, Dijie Li, Fan Zhao, Chaofei Yang, Chong Yin, Wuxia Qiu, Yunyun Xiao, Kewen Zhang, Zhiping Miao, Tuanming Yang, Airong Qian*, Circulating miR-181c-5p and miR-497-5p are potential biomarkers for prognosis and diagnosis of osteoporosis, Journal of Clinical Endocrinology & Metabolism, 2020.05.01, 105(5) pii:dgz300. 

5Xiao Lin, Qiang Chen, Yunyun Xiao, Yongguang Gao, fty Ahmed, Meng Li, Hui Li, Kewen Zhang, Wuxia Qiu, Xianhu Liu, Aldo R. Boccaccini, Airong Qian*. Phosphate glass fibers facilitate proliferation and osteogenesis through Runx2 transcription in murine osteoblastic cells. Journal of Biomedical Materials Research Part A, 2020, 108(2):316-326.

6Xiao Lin, Wuxia Qiu, Yunyun Xiao, Jianhua Ma, Fang Xu, Kewen Zhang, Yongguang Gao, Qiang Chen, Yu Li, Hui Li, Airong Qian*. MiR-199b-5p suppresses tumor angiogenesis mediated by vascular endothelial cells in breast cancer by targeting ALK1. Frontiers in Genetics, 2020, 10:1397. 

7Xiao Lin, Yunyun Xiao, Zhihao Chen, Jianhua Ma, Wuxia Qiu, Kewen Zhang, Fang Xu, Kai Dang, Airong Qian*, Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt/GSK3β/NFATc1 signalling pathway, Molecular and Cellular Endocrinology, 2019, 494:110494. 

8Suryaji Patil#, Yongguang Gao#, Xiao Lin#, Yu Li, Kai Dang, Ye Tian, Wen-Juan Zhang, Shanfeng Jiang, Abdul Qadir, Airong Qian*. The development of functional non-viral vectors for gene delivery. International Journal of Molecular Sciences, 2019, 20(21), pii:E5491. 

9Xiao Lin, Yu He, Xue Hou, Zhenming Zhang, Rui Wang, Qiong Wu*, Endothelial cells can regulate smooth muscle cells in contractile phenotype through the miR-206/ARF6&NCX1/exosome axis, PLoS One, 2016, 11(3):e0152959. 

10Xiao Lin, Li Wu, Zhenming Zhang, Ruohuan Yang, Qian Guan, Xue Hou, Qiong Wu*, MiR-335-5p promotes chondrogenesis in mouse mesenchymal stem cells and is regulated through two positive feedback loops, Journal of Bone and Mineral Research, 2014, 29(7):1575-1585. 

11Yongguang Gao, Xiao Lin, Kai Dang, Shanfeng Jiang, Ye Tian, Fenli Liu, Dijie Li, Yu Li, Zhiping Miao, Airong Qian*. Structure-activity relationship of novel low-generation dendrimers for gene delivery. Organic & Biomolecular Chemistry, 2018, 16(42):7833-7842. 

12Xiaoli Ma, Peihong Su, Chong Yin, Xiao Lin, Xue Wang, Yongguang Gao, Suryaji Patil, Abdul Rouf War, Abdul Qadir, Ye Tian*, Airong Qian*, The roles of FoxO transcription factors in regulation of bone cells function, International Journal of Molecular Sciences, 2020, 21(3): 692. 

13Kai Dang#, Wenjuan Zhang#, Shanfeng Jiang, Xiao Lin, Airong Qian*, Application of lectin microarrays for biomarker discovery. ChemistryOpen, 2020, 9(3):285-300. 

14Abdul Qadir#, Yongguang Gao#, Patil Suryaji, Ye Tian, Xiao Lin, Kai Dang, Shanfeng Jiang, Yu Li, Zhiping Miao, Airong Qian*. Non-Viral Delivery System and Targeted Bone Disease Therapy. International Journal of Molecular Sciences, 2019, 20(3), pii:E565.

15Yang Wang#, Xianli Jiang#, Shihchi Yang, Xiao Lin, Yu He, Chao Yan, Li Wu, Guoqiang Chen, Zheyao Wang, Qiong Wu*, MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern, Biomaterials, 2011, 32(35):9207-9217. 9

16Yang Wang#, Rui Gao#, Peipei Wang, Jia Jian, Xianli Jiang, Chao Yan, Xiao Lin, Li Wu, Guoqiang Chen, Qiong Wu*, The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARgamma signaling, Biomaterials, 2012, 32(2):485-493. 

17Yongguang Gao, Fenli Liu, Suryaji Patil, Dijie Li, Abdul Qadir, Xiao Lin, Ye Tian, Yu Li, Airong Qian*, 1,8-Naphthalimide-based multifunctional compounds as Cu2+ probes, lysosome staining agents, and non-viral vectors, Frontiers in Chemistry, 2019, 7:616. 

18Zhihao Chen#, Yan Zhang#, Fan Zhao, Chong Yin, Chaofei Yang, Xue Wang, Zixiang Wu, Shujing Liang, Dijie Li, Xiao Lin, Ye Tian, Lifang Hu*, Yu Li*, Airong Qian*. Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression. International Journal of Molecular Sciences, 2020, 21(4):1259.


申请发明专利: 


骞爱荣,高永光,蔺枭,胡丽芳,张文娟,罗晓庆,赵欣,李迪杰,骨靶向肽与萘酰亚胺修饰的树形高分子转基因载体、其制备方法及应用[P],申请号:201810620827.0

骞爱荣,田野,王雪,蔺枭,裴佳伟,苏佩红,印崇,谭慎行,赵欣,一种治疗骨质疏松的组合物,申请号:201910855234.7


会议报告: 

Xiao Lin, Chao Yan, Yang Wang, Qiong Wu*. MicroRNA Regulating Cell Differentiation on PHA materials, The 13th International Symposium on Biopolymers, Cairns, Australia, 7 - 10 October 2012 

Xiao Lin, et al. Microtubule actin crosslinking factor 1 (MACF1) positively controls osteoclastogenesis by regulating cell migration and fusion, 第九届国际骨质疏松和骨矿盐疾病学术会议(IOCBR 2018),优秀论文奖,2018.10

Xiao Lin, et al. Microtubule actin crosslinking factor 1 (MACF1) positively controls osteoclastogenesis and bone resorption activity,陕西省细胞生物学学会2018年年会,优秀墙报奖,2018.11

Xiao Lin, et al. Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt/GSK3β/NFATc1 signalling pathway. 2019 ASBMR Annual meeting.  Olando, USA, 19 - 23 September 2019 (poster)



荣誉获奖 Awards Information

(2015)博士研究生国家奖学金

(2011)北京市优秀毕业生;校级优秀毕业生,校级优秀党员;院级优秀毕业论文;中国农业大学食品学院本科生科技创新二等奖;

(2010)校长奖学金(学校最高荣誉);国家奖学金;中国农业大学学习优秀一等奖;校级三好学生;中国农业大学第二届“挑战杯”创业计划竞赛一等奖;中国农业大学第二届“兴农杯”创意大赛三等奖。

(2009)国家奖学金;中国农业大学学习优秀一等奖;校级三好学生;校级优秀团干部。

(2008)国家奖学金;中国农业大学学习优秀一等奖;校级优秀团员。