尚晓娅

的个人主页 http://teacher.nwpu.edu.cn/shangxiaoya

基本信息 The basic information

尚晓娅

生命学院

博士研究生毕业

工学博士

副教授

生物学

loyamuyu@nwpu.edu.cn

工作经历 Work Experience

2007-2009 西北工业大学生命学院  博士后

2009-2010 西北工业大学生命学院  讲师

2010-至今 西北工业大学生命学院  副教授  硕士生导师

2016-2017 美国约翰霍普金斯大学  访问学者

2017 英国牛津大学  学习交流

2018 德国德累斯顿工业大学  访问学者


2007-2009  Postdoctor, School of Life Sciences, Northwestern Polytechnical University.

2009-2010  Assistant Professor, School of Life Sciences, Northwestern Polytechnical University.

2010-Present  Associate Professor, Master’s Supervisor, School of Life Sciences, Northwestern Polytechnical University.

 2016-2017  Visiting Scholar, School of Medicine, Johns Hopkins University. 

2017  Teaching Training, University of Oxford.

2018  Visiting Scholar, Dresden University of Technology.




教育经历 Education Experience

1998 - 2002         武汉轻工大学         学士学位

2002 - 2007         华南理工大学         博士学位(硕博连读) 



1998-2002  Bechelor in Food Science and Engineering. Wuhan Polytechnic University.

2002-2007  PhD in Sugar Enginerring. School of Food Science and Engineering, South China University of Technology.



教育教学 Education And Teaching

本科生课程

2011-至今 春季学期 生物化学

2011-至今 春季学期 生物化学实验

2012-至今 春季学期 分子生物学实验

2018-至今 秋季学期 食物营养与食品安全

2015-2017学年秋季学期 生物学概论

2013-2016学年 生命科学导论

 

Undergraduate Courses

2011-Present Spring, Biochemistry

2011-Present Spring, Biochemistry Experiment

2012-Present Autumn, Molecular Biology Experiment

2018-Present Autumn, Food Nutrition and Food Safety

2015-2017 Autumn, Introduction to Biology

2013-2016Spring & Autumn, Introduction to Life Science

 

研究生课程

2016-至今 Advanced Biochemistry

2017-至今 春季学期 生物大分子结构与功能

2010-至今 秋季学期 生命科学导论

 

Graduate Courses

2016-Present Spring & Autumn, Advanced Biochemistry

2017-Present Spring, Structure and Function of Biomacromolecules

2010-Present Autumn, Introduction to Life Science


招生信息 Admission Information

硕士学位研究生招生专业:

071000 生物学

100702 药剂学

085238 生物工程

 

Recruit master students in Biology, Pharmaceuticsand Biological Engineering.


荣誉获奖 Awards Information

2014西北工业大学吴亚军优秀青年教师奖教金

2015西安市科学技术二等奖

2016陕西省科学技术三等奖

 

2014 Wu Yajun Scholarship for Outstanding Young Teachers of Northwestern Polytechnical University

2015 Second Prize of Science and Technology in Xi’an

2016 Third Prize of Science and Technology in Shaanxi Province


科学研究 Scientific Research

1.     主持国家自然科学基金绞股蓝寡糖GPMO结构与免疫活性的关系及其分子机制研究,项目编号:31101304,起止年月:2012.01-2014.1223万元;

2.     主持陕西省自然科学基金基于分子修饰的GPMPA化学结构与免疫活性关系及分子机制研究,项目编号:2015JM3084,起止年月:2015.01-2016.123万元;

3.     主持西安市碑林区科技计划项目菊粉对伊立替康在肿瘤化疗中产生的肠毒性的调控和预防作用研究,项目编号:GX1901,起止年月:2019.01-2020.122万元;

4.     主持中国博士后科学基金秦巴绞股蓝多糖控制性酶解片段结构与抗肿瘤活性关系的研究,项目编号:20080441194,起止年月:2008.09-2010.073万元;

5.     主持中央高校基金基本科研项目-西北工业大学基础研究基金分子修饰对GPMO免疫调节活性的影响及构效关系研究,项目编号:JCY20130150,起止年月:2013.01-2014.1215万元;

6.     主持中央高校基本科研项目-西北工业大学基础研究基金绞股蓝多糖GPMPA免疫调节活性构效关系及作用机制研究,项目编号:JC201020,起止年月:2010.07-2012.068万元;

7.    主持中央高校基本科研项目-西北工业大学科研启动基金“GPMPA化学结构和抗肿瘤活性之间的关系研究,起止年月:2009.01-2011.123万元。

 

Fundings

1.     National Natural Science Foundation of China (No.31101304, 2012-2014): Study on the Structure-Immunomodulatory Activity Relationship and Molecular Mechanisms of the Oligosaccharides from Gynostemma pentaphyllumMakino. RMB 230,000

2.     Natural Science Basic Research Plan in Shaanxi Province of China (No.2015JM3084, 2015-2016): Study on the Structure-Immunomodulatory Activity Relationship and Molecular Mechanisms of GPMPA Based on Molecular Modification. RMB 30,000

3.     Science and Technology Planning Project in Beilin District of Xi’an (No. GX1901, 2019-2020): Study on the Regulation and Prevention Effect of Inulin on Enterotoxicity of Irinotecan in Tumor Chemotherapy. RMB 20,000

4.     China Postdoctoral Science Foundation (NO.20080441194, 2008-2010): Relationship between the Structure of Controlled Enzymolysis Fragments and Antitumor Activity of polysaccharides fromGynostemma pentaphyllumMakino. RMB 30,000

5.     The Fundamental Research Funds for the Central Universities(Grant No. NPU-FFR-JCY20130150, 2013-2014): Study on the Structure-activity Relationship and Effect of Molecular Modification on Immunostimulatory Activity of GPMO. RMB 150,000

6.     The Fundamental Research Funds for the Central Universities (Grant No. NPU-FFR-JC201020, 2010-2012): Study on the Structure, immunostimulatory activity and Molecular Mechanisms of GPMPA. RMB 80,000 

7. The Fundamental Research Funds for the Central Universities (2009-2011): Study on the Relationship of Chemical Structure and Antitumor Activity of GPMPA. RMB 30,000


学术成果 Academic Achievements

发表学术论文60余篇,其中SCI收录26篇,EI收录3篇,ISTP收录2篇。以第一发明人获得授权发明专利2项。

 

Journal Publications

1.       Shang XY, Chao Y, Zhang Y, Lu CY, Xu CL, Niu WN. Immunomodulatory and antioxidant effects of polysaccharides from Gynostemma pentaphyllum Makino in immunosuppressed Mice. Molecules, 2016, 21 (8): 1085.

2.       Shang XY, Zhang Y, Bai YL, Xu CL, Niu WN, Qin CG. Extraction and Antioxidant Activities of Polysaccharides from Gynostemma pentaphyllumMakino. Asian Journal of Chemistry, 2013, 25 (16): 9092-9096.

3.       Niu WN ; Wu P ; Chen F; Wang J; Shang XY; Xu CL, Discovery of selective cystathionine beta-synthase inhibitors by high-throughput screening with a fluorescent thiol probe , MedChemComm, 2017, 8(1): 198-201. 

4.       Xu CL ; Guo Y; Qiao XJ; Shang XY; Niu WN; Jin ML , Design, Recombinant Fusion Expression and Biological Evaluation of Vasoactive Intestinal Peptide Analogue as Novel Antimicrobial Agent , Molecules, 2017.11, 22(11): 1963.

5.       Li Y; Shang XY; Niu WN; Xu CL; Qin CG , Inhibitory Activity of the Extract from Broussonetia papyrifera Fruits to Cellular Lipid Peroxidation in vitro , Asian Journal of Chemistry, 2014.1, 26(1): 201-204. 

6.       Xu CL, Sun R, Zhao YF, Qiao XJ, Shang XY, Niu WN. Resveratrol ameliorates chronic high altitude exposure-induced oxidative stress and lipid metabolism alteration in rats. European Journal of Lipid Science and Technology.2015, 117, DOI: 10.1002/ejlt.201400426.

7.       Xu CL, Wang YM, Sun R, Qiao XJ, Shang XY, Niu WN. Modulatory effects of vasoactive intestinal peptide on intestinal mucosal immunity and microbial community of weaned piglets challenged by an Enterotoxigenic Escherichia coli (K88). PLOS One . 2014, 9: e104183.

8.       Xu CL, Sun R, Qiao XJ, Xu CC, Shang XY, Niu WN, Chao Y. Effect of vitamin E supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment. Korean Journal of Physiology & Pharmacology. 2014,18:1-8.

9.       Xu CL, Sun R, Qiao XJ, Xu CC, Shang XY. Niu WN. Protective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment. World Journal of Gastroenterology. 2014, 20(16): 4467-4838.

10.    Xu CL, Zhao YF, Shang XY, Niu WN. Effects of diet-derived rhizomes of Atractylodes macrocephala Koidz on growth performance and immune function in piglets. Journal of Animal and Feed Sciences. 2012, 21(2): 302-312.

11.    Xu CL, Qin CG, Zhang RJ, Niu WN, Shang XY. Solid-phase synthesis and antibiotic activities of cyclodecapeptides on the scaffold of naturally occurring laterocidin. Bioorganic & Medicinal Chemistry Letters.2010, 20(1): 164-167. 

12.    Qin CG, Li Y, Li HL, Li DW, Niu WN, Shang XY, Xu CL. Novel progresses in synthesis strategies of aromatic azo derivatives. Chinese Journal of Organic Chemistry, 2013, 33 (3): 444-457. 

13.    Qin CG, Li Y, Niu WN, Ding Y, Shang XY, Xu CL. Composition analysis and structural identification of anthocyanins in fruit of waxberry. Czech Journal of Food Sciences, 2011, 29 (2): 171-180. 

14.    Qin CG, Xu CL, Zhang RJ, Niu WN, Shang XY. On-resin cyclization and antimicrobial activity of Laterocidin and its analogues. Tetrahedron Letters, 2010, 51: 1257-1261. 

15.    Qin CG, Li Y, Niu WN, Ding Y, Zhang RJ, Shang XY. Analysis and characterization of anthocyanins in mulberry fruit. Czech Journal of Food Science, 2010, 28 (2): 117-126.

16.    Shang XY, Fu X, Chen XD, Yang LS. Biodegradation of blends of polyethylene-octene elastomer with starches by fungi. Journal of Applied Polymer Science, 2009, 114 (6): 3574-3584.

17.    Shang XY, Chen XD, Fu X, Yang LS. Biodegradation of polyethylene-octene elastomer-starch composites in soil. Journal of Reinforced Plastics and Composites, 2009, 28 (3): 279-293.

18.    Shang XY, Xu CL, Niu WN, Qin CG. Antioxidant properties of polysaccharides from Dioscorea opposite Thunb roots.Proceedings of 2009 International Conference of Natural Product and Traditional Medicine, 2009, Vols 1 and 2: 268-272.

19.    Shang XY, Fu X, Yang LS, Chen XD, Zhang MQ. Influence of compatibilizer on morphology and dynamic rheological behavior of polyethylene-octene elastomer/starch blends. International Journal of Polymeric Materials, 2008, 57 (4): 362-373.

20.    Shang XY, Fu X, Yang LS, Chen XD. Structure and water absorption of starch and polyethylene-octene elastomer composites. Journal of Reinforced Plastics and Composites, 2008, 27 (4): 375-391.

21.    Shang XY, Fu X, Yang LS, He XW, Wen RG. Kinetics of non-isothemal degradation of polyethylene-octene elastomer/starch blends. Journal of South China university of Technology (Natural Science), 2007, 35 (7): 93-98.

 

Patent

1.    Shang XY, Bai YL, Liu H, et al. A Process for preparing the sulfated polysaccharides from Gynostemma pentaphyllumMakino. Patent application ZL201410705721.2.

2.  Shang XY, Qin CG, Xu CL, et al. A Process for preparing a neutral polysaccharide from Gynostemma pentaphyllumMakino. Patent application ZL200910023912.X.


社会兼职 Social Appointments

九三学社陕西省第十三届委员会委员

陕西省药学会药物化学专业委员会委员

陕西省天然药物学会理事

中国生物化学与分子生物学会会员

 

Committee Member of the 13thShaanxi Provincial Committee of Jiusan Society

Committee Member of Pharmaceutical Chemistry Professional Committee of Shaanxi Pharmaceutical Association

Director of Shaanxi Natural Medicine Association 

Member of Chinese Society of Biochemistry and Molecular Biology