王万河


的个人主页 http://teacher.nwpu.edu.cn/wanhelab

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基本信息 The basic information

王万河

医学研究院

博士研究生毕业

哲学博士

副教授

药学,化学

whwang0206@nwpu.edu.cn

工作经历 Work Experience

2019/12-至今   西北工业大学医学研究院   副教授

2014/10-2015/11   香港浸会大学   科研助理

教育经历 Education Experience

2015/12-2019/09   香港浸会大学    化学    哲学博士

2017/08-2017/08   Monash University(澳大利亚)   海外交流计划

2011/09-2014/06   吉林大学   药物化学   医学硕士

2007/09-2011/07   昆明理工大学   制药工程   工程学士

综合介绍 General Introduction

       本课题组面向生命健康领域重大疾病防治等重大科学问题,从(1)过渡金属配合物类肿瘤诊疗探针开发;(2)过渡金属配合物类靶向药物发现;(3)基于天然产物的虚拟药物筛选三个方面开展基础研究。目前,课题组负责人已在Nature Communications, Angewandte Chemie International Edition, Chemical Science, Journal of Medicinal Chemistry等知名国际期刊上发表SCI论文60余篇,申请国际及中国发明专利5篇其中以第一作者、通讯作者发表28篇(7篇被选为封面或封底文章),总被引次数1600余次,H-Index23。担任国际期刊Frontiers in Oncology (IF: 6.244)的Guest Associate Editor和Frontiers in Chemistry (IF: 5.221)的Review Editor。

学术成果 Academic Achievements

Selected Publications:

After 2020 (PI)

[1] W. Wang, K.-J. Wu, K. Vellaisamy, C.-H. Leung*, D.-L. Ma*. "Peptide-conjugated long-lived theranostic imaging toolbox fortargeting GRPr in cancer and immune cells ". Angew. Chem. Int. Ed., 2020, 59, 17897. (Impact factor: 15.336, Inside cover, 化学一区)

[2] G. Li, C.-N. Ko, D. Li, C. Yang, W. Wang, G.-J. Yang, C. D. Primo, V. K. W. Wong, Y. Xiang, L. Lin*, D.-L. Ma*, C.-H. Leung*. “A small molecule HIF-1α stabilizer that accelerates diabetic wound healing”. Nat. Commun., 2021, 12, 3363. (Impact factor: 14.919, 综合一区)

[3] W. Wang, T.-L. Yung, S.-S. Cheng, F. Chen, J.-B. Liu, C.-H. Leung, D.-L. Ma*. “A long-lived luminogenic iridium(III) complex for acetylacetone detection in environmental samples” Sens. Actuator B-Chem., 2020, 321, 128486. (Impact factor: 7.460, 化学一区)

[4] S. Cheng, G.-J. Yang, W. Wang (co-first author), D.-L. Ma*, C.-H. Leung*. Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein-protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells”. Genes Dis., 2021, DOI: 10.1016/j.gendis.2021.06.005 (Impact factor: 7.103, 化学一区)

[5] S.-S. Cheng, G.-J. Yang, W. Wang, C.-H. Leung*, D.-L. Ma*. "The design and development of covalent protein-protein interaction inhibitors for cancer treatment". J. Hematol. Oncol., 2020, 13, 26. (Impact factor: 17.388, 医学一区)

[6] G. Li, H. Liu, R. Feng, T.-S. Kang, W. Wang, C.-N. Ko, C.-Y. Wong, M. Ye, D.-L. Ma*, J.-B. Wan, C.-H. Leung*. "A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury". Redox. Biol., 2021, 48, 102129 (Impact factor: 11.799, 生物一区)

[7] G.-J. Yang, W. Wang (co-first author), P.-M. Lei, C.-H. Leung*, D.-L. Ma*. "A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy". Int. J. Biol. Macromol., 2020, 164, 3204. (Impact factor: 6.953, 医学二区)

[8] Liu Yang, Qingxin Chen, Shenglong Gan, Qiang Guo, Jie Zhang, Huatang Zhang, Yusheng Xie, Hanyue Xiao, W. Wang (Corresponding author), Hongyan Sun. "An activatable AIEgen probe for in-situ monitoring and long-term tracking of ferrous ions in living cells". Dyes Pigm., 2021, 190, 109271. (Impact factor: 4.889, 化学二区)

[9] C. Wu, K.-J. Wu, J.-B. Liu, W. Wang, C.-H. Leung*, D.-L. Ma*. "Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect". Chem. Sci., 2020, 11, 11404. (Impact factor: 9.825, Front cover, 化学一区)

[10] S.-S. Chen, Y.-Q. Quan, J. Wu, G.-J Yang, H. Liu,  W. Wang, Q. Huang, F. Chen, G. Li, C.-Y. Wong, V. K. Y. Wong, D.-L. Ma*, C.-H. Leung*. "Inhibition of the CDK9?cyclin T1 protein?protein interaction as a new approach against triple-negative breast cancer". Acta Pharmaceutica Sinica B, 2022, 12, 1390. (Impact factor: 11.614, 医学一区)



Before 2020

[1] G.-J. Yang, W. Wang (co-first author), W.-F. S. Mok, C. Wu, Y.-K. B. Law, X.-M. Miao, K.-J. Wu, H.-J. Zhong, C.-Y. Wong, K.-W. V. Wong*, D.-L. Ma*, C.-H. Leung*. "Selective inhibition of lysine-specific demethylase 5A (KDM5A) using a rhodium(III) complex for triple-negative breast cancer therapy". Angew. Chem. Int. Ed., 2018, 57, 13091. (Impact factor: 15.336, Inside back cover, 化学一区)

[2] W. Wang, K. Vellaisamy, G. Li, C. Wu, C.-N. Ko, C.-H. Leung*, D.-L. Ma*. "Development of a long-lived luminescence probe for visualizing β-galactosidase in ovarian carcinoma cells". Anal. Chem., 2017, 89, 11679. (Impact factor: 6.986, 化学一区)

[3] W. Wang, Z. Mao, M. Wang, L.-J. Liu, D. W. J. Kwong, C.-H. Leung, D.-L. Ma*. “A long lifetime luminescent iridium(III) complex chemosensor for selective switch-on detection of Al3+ ions” Chem. Commun., 2016, 52, 3611. (Impact factor: 6.222, Inside front cover, 化学一区)

[4] L.-J. Liu, W. Wang (co-first author), S.-Y. Huang, Y. Hong, G. Li, S. Lin, J. Tian, Z. Cai, H.-M. D. Wang, D.-L. Ma*, C.-H. Leung. “Inhibition of the ras/raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(III) metal-based compound” Chem. Sci., 2017, 8, 4756. (Impact factor: 9.825, Inside back cover, 化学一区)

[5] K. Vellaisamy, G. Li, W. Wang (co-first author), C.-H. Leung,* D.-L. Ma*. “A long-lived peptide-conjugated iridium(III) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2” Chem. Sci., 2018, 9, 8171. (Impact factor: 9.825, Front cover, 化学一区)

[6] W. Wang, C. Yang, S. Lin, K. Vellaisamy, G. Li, W. Tan, C.-H. Leung, D.-L. Ma*. “First synthesis of an oridonin-conjugated iridium(III) complex for the intracellular tracking of NF-κB in living cells” Chem. Eur. J., 2017, 23, 4929. (Impact factor: 5.236, 化学二区)

[7] W. Wang, C. Yang, G. Li, Y.-C. Tse, C.-H. Leung, D.-L. Ma*. “An iridium(III) complex-based chemosensor for the detection of thiourea in living cells” Sens. Actuator B-Chem., 2017, 251, 374. (Impact factor: 7.460, 化学一区)

[8] W. Wang, C. Wu, C. Yang, G. Li, Q.-B. Han, S. Li, M.-Y. Lee, C.-H. Leung, D.-L. Ma*. "A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells". Sens. Actuator B-Chem., 2018, 255, 1953. (Impact factor: 7.460, 化学一区)

[9] W. Wang, L. Lu, C. K.-J. Wu, J. Liu, C.-H. Leung, C.-Y. Wong, D.-L. Ma*. "Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells". Sens. Actuator B-Chem., 2019, 288, 392. (Impact factor: 7.460, 化学一区)  

[10] C. Yang, W. Wang (co-first author), J. Liang, G. Li, K. Vellaisamy, C.-Y. Wong, D.-L. Ma*, C.-H. Leung. “A rhodium(III)-based inhibitor of lysine-specific histone demethylase 1 as an epigenetic modulator in prostate cancer cells” J. Med. Chem., 2017, 60, 2597. (Impact factor: 7.446, 医学一区)


Selected Patents:

[1] 喹唑啉类化合物、其中间体、制备方法、药物组合物和应用, 柏旭, 余建鑫, 王万河, 张永, 郑连友, 夏广新, 张春玲, 王余吉, 周倩, 张大鹏(CN106316965A), 2017/01/11.

[2] Quinazoline compound, intermediate, preparation method, pharmaceutical composition and uses thereof, 柏旭, 余建鑫, 王万河, 张永, 郑连友, 夏广新, 张春玲, 王余吉, 周倩, 张大鹏(WO2017005137A1), 2017/01/12.


Selected Fundings (PI):

国家自然科学基金青年项目,主持,2022.01-2024.12

陕西省基础研究计划青年项目,主持,2021.01-2022.12

重庆市自然科学基金面上项目,主持,2021.10-2024.09

海南省重点研发计划社发领域项目,联合主持,2021.12-2023.12

中央高校基本业务资助项目,主持,2020.01-2021.12

横向经费:肿瘤诊疗探针的设计与开发,主持,2021.10-2022.10



荣誉获奖 Awards Information

2017 中国分析测试协会科学技术三等奖(中国分析测试协会)

2017 亚坤内地研究生奖学金计划(香港浸会大学)

招生信息 Admission Information

课题组研究方向:

A. 有机金属配合物(铱、钌等)的发光机理研究肿瘤诊断探针开发;

B. 有机金属配合物(铱、钌、铑等)和生物大分子的作用机制研究靶向金属药物开发;

C. 计算机辅助药物设计(ICM)及天然产物类药物发现

硕士期间,课题组提供海外交流机会,表现优秀者,可推荐至海外高校攻读博士。


欢迎各位有志学子报考我院硕士研究生!

接受推免生

欢迎广大化学、药学背景的有志学子加入本课题组!

联系方式:wanhewang1988@hotmail.com/whwang0206@nwpu.edu.cn

学术活动 Professional Activities

2022   PIERS2022, "Peptide-conjugated luminescent iridium(III) complexes as biocompatible theranostic probes for cancer and immune systems", Oral Presentation, Hangzhou, China

2017   5th MacroTrend Conference on Applied Science: Paris 2017, "Iridium complex-based probe for visualizing β-galactosidase in ovarian carcinoma cells", Oral Presentation, Paris, France