武祥龙

的个人主页 http://teacher.nwpu.edu.cn/wuxianglong

  被浏览次数:7501

基本信息 The basic information

武祥龙

生命学院

博士研究生毕业

博士

副教授

生物医学工程

wuxianglong@nwpu.edu.cn

工作经历 Work Experience

2013年1月至2014年4月西北工业大学生命学院讲师;2014年4月至今生命学院副教授。其中,2019年3月至2020年3月在南洋理工大学材料与科学工程学院访学。



2014.05-present Associate professor, School of Life Science, Northwestern Polytechnical University

2012.12-2014.04 Lecturer, School of Life Science, Northwestern Polytechnical University

2010.06-2012.12 Postdoctoral Fellow, School of Life Science, Northwestern Polytechnical University

 

教育经历 Education Experience

2001年至2005年西北大学材料化学专业读本科

2005年至2010年西北大学有机化学硕博连读

20107月至201212月西北工业大学生命学院博士后


2005.09-2010.06 Master Degree and Ph.D. of Organic Chemistry, College of Chemistry & Materials Science, Northwest University (China)

2001.09-2005.07 Bachelor Degree of Materials Chemistry, Department of Chemistry, Northwest University (China)


教育教学 Education And Teaching

研究方向:

荧光探针设计合成及应用、航天员空间骨丢失机理及其防护药物研究、药物设计合成及生物活性研究、生物材料;


Research interests:

fluorescent probesriluzole derivatives antitumor activity and molecular mechanismriluzole derivatives peripheral analgesic effect on neuropathic pain and their mechanism;Biologicalmaterials

 



主讲课程:

本科生专业课《人体解剖生理学》 

本科生专业基础课《有机化学》

本科生综合素养课《文献检索与论文写作》

研究生专业课《药物代谢与药物分析》 


Course:

Human Anatomy and PhysiologyOrganic Chemistry

Information Retrieval and Academic Writing

Pharmacokinetics and Pharmaceutical Analysis



教学荣誉

2016年首届卓越联盟青年教师讲课比赛三等奖;

2017年西北工业大学最满意教师称号;

2017年优秀班主任称号;

2018年陕西省第三届微课教学比赛三等奖

教改项目:

2016年获批1项校级在线开放课程建设项目《人体解剖生理学》;

2016年获批1项教学与考核模式改革项目;

中国大学mooc主讲《人体解剖生理学

网址链接https://www.icourse163.org/course/NWPU-1002527016

2019年《人体解剖解剖生理学》获得陕西省精品在线课程称号;

中国大学mooc主讲《文献检索与论文写作》

课程网址链接:https://www.icourse163.org/course/NWPU-1206520804

2020年西北工业大学教学比赛二等奖

2020年获教改项目1项,数字课程《文献检索与论文写作》出版资助1项;



2020.6  Second Prize of Teaching Competition in Northwestern Polytechnical University

2018.5   Third Prize of Teaching Competition in Shaanxi Province

2016.06     Third Prize of Teaching Competition in Northwestern Polytechnical University

2009        Academic Scholarship for Excellent meeting paper

2002-2005   Northwest University Excellent Academic Scholarship

2002-2005   Cyrus Tang Foundation Scholarship



2016&2019 Two Massive Open Online Courses

2016&2017 Project on educational reform 


 

 

招生信息 Admission Information

硕士研究生招生专业:生物医学工程、生物与医药工程


The main major for recruiting master students: Biomedical engineering; Biological and medical engineering

科学研究 Scientific Research


国家自然科学基金青年项目(21202130),用于标记糖的荧光探针的设计合成及其示踪寡糖吸收机制研究2013~2015 

陕西省自然科学基金面上项目(2015JM2067),利鲁唑衍生物的合成及其镇痛作用机制研究2015.1-2016.12

中央高校基本科研业务费专项资金资助(3102014JKY15005),利鲁唑衍生物的合成及其镇痛作用机制研究 2014.05-2016.05

企业横向课题:(2018ME180014C180014)氟比洛芬甲酯的合成及其药物剂型研究,2018.52020.5

陕西省自然科学基金面上项目 (No.2019JM-152) 利鲁唑及其衍生物对HeLa细胞抗肿瘤作用和机制研究,2019.12020.12

2019.3.102020.3.14  西北工业大学青年教师国际名校访学支持计划

中央高校基本科研业务费专项资金资助,具有光热响应的可控释药介孔二氧化硅纳米涂层研究2020年)


 

2013.01-2015.12 Synthesis and design of fluorescent carbohydrate-labeling probes and study on its mechanism of absorption, the National Natural Science Foundation of China (No. 21202130)

2014.04-2016.04 Research on riluzole derivatives analgesic effect on neuropathic pain and their mechanism, the Fundamental Research Funds for the Central Universities (No. 3102014JCQ15005)

2015.01-2016.12 Research on riluzole derivatives peripheral analgesic effect on neuropathic pain and their mechanism, the Natural Science Foundation Research Project of Shaanxi Province (No.2015JM2067)

2017.1-2020.12 Research on riluzole derivatives antitumor activity and molecular mechanism, the Natural Science Foundation Research Project of Shaanxi Province (No.2019JM-152)

2019.3 to 2020.3  Top International University Visiting Program for Outsanding Young scholars of Northwestern Polytechnical University




 


 

学术成果 Academic Achievements

部分学术成果:

  1. Wu Xianglong, Liu Liu, Wang Qingchuan, Wang Haifang, Zhao Xiangrong, Lin Xubin, Lv Wenjun, Niu Yinbo, Lu Tingli, Qi Bingmei. Antitumor activity and mechanism study of riluzole and its derivatives [J]. Iranian Journal of Pharmaceutical Research, 2020, 19(3): 217-230

  2. Xianglong Wu, Zhihui Chen, Wangqiao Chen, Fei Yu, Guofu Zhou*, Qinghua Xu*, and Qichun Zhang*, Two-photon absorption of butterfly-shaped carbonyl-bridged twistarene [J]. Asian Journal of Organic Chemistry 2020, 9, 579–583.

  3. Jin X L,Wu X L(co-first author), Zhang F, Zhao H Q, Zhong W, Cao Y X, Ma X H, Leng X, Zhou H W, She M Y, Cu2+/ATP reversible ratiometric fluorescent probe through strip, hydrogel, and nanofiber, and its application in living cells and edaphic ecological safety assessment [J]. Dyes and Pigments, 2020,182,108677.

  4. Wu X L, Wang Q C, Zhang F, Liu H, Lu T L, Zhang Q C. Preparation and in vivo atinociceptive behavior of four new 2-amino-6-trifuromethoxybenzothiazole carboxylic acid derivatives [J]. ChemistrySelect 2019, 4, 9993-9998.

  5. Dong K, Lei Q, Guo R, Wu X L, Zhang Y, Cui N, Shi J Y, Lu T. Regulating intracellular ROS signal by a dual pH/reducing-responsive nanogels system promotes tumor cell apoptosis[J]. International Journal of Nanomedicine, 2019, 14, 5713-5728.

  6. Lu C B , Wu X L(co-first author), Ma H Z, Wang Q C, Wang Y K, Luo Y, Li C, XU H. Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke[J]. Neural Plasticity, 2019, 1-9.

  7. 张飞,刘振国, 王海芳, 武祥龙*, 刘柳, 蔺旭彬, 吕文君,刘浩.2-(N-丙基)-6-三氟甲氧基苯并噻唑抗肿瘤活性研究[J]. 中国药理学通报, 2019, 35(05):644-648.

  8. Wu X L, Liu L, Li Y J, et al. Synthesis, crystal structure, and antinociceptive effects of some new riluzole derivatives[J]. Medicinal Chemistry Research, 2018, 27: 1374–1383.

  9. Jing X L, Wu X L(co-first author), et al. Reaction-Based Fluorescent Probes for rapid detection of hydrogen sulfide in vivo[J]. Analytical Methods, 2018,10:4079-4084

  10. Jing X L, Wu X L(co-first author), et al. A reversible fluorescent probe for Zn2+ and ATP in living cells andin vivo[J]. Sensors and Actuators B, 2018, 261(5):127-134.

  11. Jin X, Wu Xianglong(co-first author), Liu L, et al. Dual-Functional Fluorescein-Based Chemosensor for Chromogenic Detection of Fe3+, and Fluorgenic Detection of HOCl [J]. Journal of Fluorescence, 2017(4):2111-2117.

  12. 张飞, 刘柳, 汪晴川, 蔺旭彬, 吕文君, 梅其炳, 武祥龙*.宫颈癌HeLa细胞调控信号通路研究新进展, 化学与生物工程2018, 35(2):1-7.

  13. 汪晴川,刘柳,徐小康,盖冬玮,梅其炳,武祥龙*AMPA受体变构调节剂CX516药理学研究进展[J]. 化学与生物工程2017, 34(6):1-5.

  14. 刘柳汪晴川盖冬玮徐小康,徐强强,贺聪,陈威,梅其炳,武祥龙*利鲁唑在神经保护、镇痛及抗抑郁领域的研究进展[J]. 化学与生物工程2017, 34(2):6-9.

  15. 武祥龙*,刘柳,李游嘉,罗杰,盖冬玮,马景川,梅其炳, 2-(N-环己胺)-6-三氟甲氧基苯并噻唑的合成及其晶体结构,合成化学,20164346 ~ 349

  16. 刘柳,马景川,盖冬玮,张妍,冯昕,马梦瑶,张明,武祥龙*,用于检测巯基化合物的荧光探针的研究进展,化学与生物工程,2016021~ 7

  17. 武祥龙, 李海亮, 卢娜, 牛银波, 李晨睿, 梅其炳. 苯并噻唑衍生物的生物活性及其构效关系研究进展. 化学与生物工程, 2014, 5:1-6+9.

  18. 武祥龙. 寡糖生物活性及其标记技术研究进展. 山东化工, 2015, 44(3): 40-45.

  19. 武祥龙. 利鲁唑药理学作用研究进展. 中国药学杂志,2015, 50(14):1165-1168.

  20. 商澎, 呼延霆, 杨周岐, 武祥龙, 赵玉芬, 赵国屏, 顾逸东. 中国空间生命科学的关键科学问题和发展方向. 中国科学: 技术科学,2015, 45:1-13.

  21. X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives. Molecules 2014, 19: 1034-1046.

  22.  X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, spectroscopic properties, and biological applications of eight novel chlorinated fluorescent proteins-labeling probes, J.Fluoresc. 2014, 24(3): 775-786.

  23.  X. L. Wu, X. L. Jin, Y. X. Wang, J. L. Li, Z. Shi, “Synthesis and spectral properties of novel chlorinated pH fluorescent probes”. J. Lumin. 2011, 131(4): 776-780

  24. W.T. Fan, X. L. Wu, Y. L. Pan, et al. “1-(1, 3-Benzodioxol-5-yl-carbo-nyl) piperidine, a modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice”. Biol. Pharm. Bull. 2014, 37(1):13–17.

授权专利:

[1]武祥龙,范於菟,孔祥鹤,王娟,刘莉,梅其炳,国家发明专利苯甲酰胺化合物及其制备方法ZL201110148165.X

[2]武祥龙,刘柳,汪晴川,卢婷利,梅其炳,2-N-乙基)-6-三氟甲氧基苯并噻唑作为抗癌药物的应用,2017.3,专利号:ZL201710204425.8

[3]武祥龙,刘柳,汪晴川,卢婷利,梅其炳,利鲁唑在抑制金黄色葡萄球菌方面的应用,申请日期,20171 ,授权号:ZL 201710005771.3,授权日期2020616

申请专利:

[1]武祥龙,刘柳,汪晴川,卢婷利,梅其炳,利鲁唑在抑制金黄色葡萄球菌方面的应用,申请日期,20171 ,申请号:201710005771.3

[2] 武祥龙,张飞,刘浩,魏春龙,袁民政,张科强. 氟比洛芬美普他酚酯药用化合物及其制备方法, 2018.11, 申请号:201811250880.2

[3] 武祥龙,张飞,刘浩,陈强,董凯,卢婷利.具有荧光成像和载药双功能的介孔二氧化硅纳米材料的制备方法, 2018.11, 申请号:201811250870.9