徐春兰

的个人主页 http://teacher.nwpu.edu.cn/xuchunlan

  被浏览次数:6078

基本信息 The basic information

徐春兰

生命学院

博士研究生毕业

博士

副教授

生物学

工作经历 Work Experience

2008-2010   西北工业大学生命学院 博士后

2010-2011   西北工业大学生命学院 讲师

2011-至今    西北工业大学生命学院副教授  博士生导师

2014-2015   加州大学洛杉矶分校访问学者


2011~   Associate Professor, Doctor's Supervisor, School of Life Sciences, Northwestern Polytechnical University.

2014-2015 Visiting Scholar, University of California, Los Angeles

2010-2011 Lecturer, School of Life Sciences, Northwestern Polytechnical University.

2008-2010 Postdoctor, School of Life Sciences, Northwestern Polytechnical University.


教育经历 Education Experience

1998-2002年  华中农业大学  攻读学士学位

2003-2008年  浙江大学        攻读硕-博士学位 


1998-2002  Bechelor, Huazhong Agricultural University

2003-2008  Master-PhD, Zhejiang University   



教育教学 Education And Teaching

本科生课程:

本科生专业基础课《生物化学》

本科生专业选修课《营养学》

本科生实验课《生物化学实验》

本科生实验课《分子生物学实验》

研究生课程:

《高级生物化学实验技术》

《生命科学导论》

《生物技术与工程》


Undergraduate Courses

Biochemistry

Nutrition

Biochemical experiment

Molecular biology experiment

Graduate Courses

Advanced biochemical experimental techniques

Introduction to life sciences

Biotechnology and engineering

招生信息 Admission Information

硕士学位研究生招生专业:

071009 生物学

083100 生物医学工程

0860 生物与医药

Recruit master students in Biology, Biomedical Engineering and Biology & Medicine. 

士学位研究生招生专业:

083100 生物医学工程

Recruit Ph.D students in Biomedical Engineering . 



荣誉获奖 Awards Information

2011-2012年度西北工业大学本科生奖教金

2011-2012年度西北工业大学“优秀青年教师”

2013年“西北工业大学吴亚军优秀青年教师奖教金”(一等)

2013年“西北工业大学优秀班主任” 

2015-2016 西北工业大学先进女教职工工作者、“三八红旗手”


2011-2012  Undergraduate Scholarship of Northwester Polytechnical University

2011-2012 Outstanding Young Teacher of Northwester Polytechnical University

2013 Wu Yajun, Outstanding Young Teacher of Northwester Polytechnical University (The first prize)

2013 Excellent Class Teacher of Northwester Polytechnical University

2015-2016 Advanced Female Faculty and Staff member, "March Eighth Flag-Bearer" of Northwester Polytechnical University 

科学研究 Scientific Research

从事的研究方向:

1)神经肽介导的微生物-脑-肠轴对肠道屏障功能的调控机制

2)动物源性防御肽-必需微量元素-益生菌类复合微生态制剂的研制

3)低压低氧环境下的生物学效应及其防护研究 

Research directions

(1) The regulatory mechanism of neuropeptide-mediated microbial-brain-gut axis on intestinal barrier function

(2) Development of complex microecological agent based on animal derived defense peptides, essential trace elements and probiotics

(3) Biological effects and protection in hypoxia environment

承担的研究项目:

国家自然科学基金-面上项目(31672435)

国家自然科学基金-青年项目(31001012)

陕西省重点研发计划项目(2018NY-102)

陕西省科学技术研究发展计划项目(2013K02-16)

中国博士后特别资助基金(201003686)

中国博士后科学基金(一等)(20080440195)、

中央高校基本科研业务费资助项目(3102015BJ(Ⅱ)MYZ29)

西北工业大学基础研究基金(JC201278)

西北工业大学科技创新基金(2008KJ02040) 

Research projects

National natural science foundation of China (31672435)

National natural science foundation of China (31001012)

Shaanxi key research and development program (2018NY-102)

Shaanxi province science and technology research and development program (2013K02-16)

Special grant for postdoctoral students in China (201003686)

Chinese postdoctoral science foundation (first class) (20080440195),

The basic scientific research in colleges and universities were funded projects (3102015 BJ(Ⅱ) MYZ29)

The Fundamental Research Funds for the Central Universities (JC201278)

Technology innovation fund of Northwester Polytechnical University (2008KJ02040)


学术成果 Academic Achievements

Publications

1. Chunlan Xu* , Lei QiaoLi Ma, Yu Guo, Xian Dou, Shuqi Yan, Baohua Zhang, Alexandra Roman. Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 alleviate intestinal epithelial barrier dysfunction caused by oxidative stress via Nrf2 signaling-mediated mitochondrial pathway. International Journal of Nanomedicine. 2019, 14: 4491-4502.

2.Chunlan Xu*, Lei Qiao1, Li Ma, Shuqi Yan, Xina Dou, Baohua Zhang, Alexandra Roman.

Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized by Lactobaccillus casei ATCC 393. Frontiers in Microbiology. 2019, doi: 10.3389/fmicb.2019.01632

3. Chunlan Xu* , Yu GuoLei QiaoLi MaYi-yi Cheng. Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized by Lactobaccillus casei ATCC 393. Carbohydrate Polymers. 2018, 195: 576-585.

4Chunlan Xu* , Yu GuoLei QiaoLi MaYiyi Cheng, Alexandra Roman. Biogenic synthesis of novel functionalized selenium nanoparticles by Lactobacillus casei 393 and its protective effects on intestinal barrier dysfunction caused by Enterotoxigenic Escherichia coli K88. Frontiers in Microbiology. 2018, 9: 1129.

5. Chunlan Xu* , Yu GuoLei QiaoLi MaYiyi Cheng. Recombinant vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats. World Journal of Gastroenterology. 2018,24(6):706-715.

6. Chunlan Xu*Yu GuoXiangjin QiaoXiaoya ShangWeining NiuMingliang Jin*Design, recombinant fusion expression and biological evaluation of vasoactive intestinal peptide analogue as novel antimicrobial agent. Molecules. 2017, 22:1963.

7. Chunlan XuSally GhaliJiani Wanget al. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway. Scientific Reports. 2017, 7:16351

8. Chunlan Xu*, XJ Qiao, Y.F.Zhao, R.Sun, X.Y.Shang, W.N.Niu. Resveratrol ameliorates chronic high altitude exposure-induced oxidative stress and lipid metabolism alteration in rats. European Journal of Lipid Science and Technology. 2016, 118:612-621.

9. Chunlan Xu*Youming Wang; Rui SunXiangjin QiaoXiaoya ShangWeining NiuModulatory Effects of Vasoactive Intestinal Peptide on Intestinal Mucosal Immunity and Microbial Community of Weaned Piglets Challenged by an  Enterotoxigenic Escherichia coli (K88). PLos One. 2014, 9(8):e104183.

10. Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.NiuProtective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment. World Journal of Gastroenterology. 2014, 20(16): 4467-4838.

11. Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.Niu, Y. ChaoEffect of vitamin E supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment. Korean Journal of Physiology & Pharmacology. 2014,18:1-8.

12. Chunlan Xu*, C.Dong, C.C.Xu, T.T. Han, S.Bao, X.B.Gao. Effect of iron glycinate chelate on the expression of hypoxia-inducible factor and antioxidant status in rats exposed to high altitude hypoxia environment. Biological Trace Element Research. 2014, 162:142-152.

13. C.L.Xu*, Y.F. Zhao,X.Y.Shang, W.N.Niu. Effects of diet-derived rhizomes of Atractylodes macrocephala Koidz on growth performance and immune function in piglets. Journal of Animal and Feed Sciences. 2012, 21(2): 302-312.

14. C.L.Xu, C.G.Qin, R.J.Zhang, W.N.Niu, X.Y.Shang. Solid-phase synthesis and antibiotic activities of cyclodecapeptides on the scaffold of naturally occurring laterocidin. Bioorganic & Medicinal Chemistry Letters.2010, 20(1): 164-167. 

15. C.L.Xu, Y.Z.Wang, M.L.Jin, X.Q.Yang. Preparation, characterization and immunomodulatory activity of selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacae Z0206Bioresource Technology. 2009, 100(6): 2095-2097. 

16. Jiani Wang, Sally Ghali, Chunlan Xu, et al. Ceragenin CSA13 reduces Clostridium difficile infection in mice by modulating the intestinal microbiome and metabolites. Gastroenterology. 2018, 154(6): 1737-1750.

17. Hon Wai Koon, Bowei Su, Chunlan Xu, et al. Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. American Journal of Physiology- Gastrointestinal and Liver Physiology. 2016, 311(4):G610-G623.


社会兼职 Social Appointments

陕西省药学会药物化学委员会委员,中国生物化学与分子生物学会会员